Attention Training for Childhood Obsessive Compulsive Disorder: An Open Case Series
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Psychiatric |
| Therapuetic Areas: | Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 8 - 17 |
| Updated: | 4/21/2016 |
| Start Date: | November 2012 |
| End Date: | August 2016 |
Pediatric Obsessive Compulsive Disorder (OCD) is a chronic, impairing condition that accrues
significant concurrent and long-term risk to affected youth. Although empirically supported
psychosocial and pharmacological treatments for OCD exist, many children and their families
are not able to adequately access these treatments or derive only partial benefit from them.
Such findings highlight the importance of developing more effective treatment options which
have the potential to be widely accessible to OCD youth.
The investigators are proposing to test a computerized attention modification program, AMP,
in six youth with OCD in an open case series to gather information regarding protocol
acceptability, feasibility and preliminary efficacy. This phase includes the development and
refinement of stimuli selection procedures, behavior avoidance task, EEG protocol, and AMP
parameters for use with children.
Following ascertainment of study eligibility, participants will undergo a baseline
assessment consisting of a clinical interview, neurocognitive assessments, EEG, attention
bias assessment, and self report questionnaires. Study participants will then receive 12
sessions of AMP treatment over the course of three weeks. All youngsters and their families
will be reassessed at treatment endpoint (week 4). Participation will take a total of about
24 hours over the course of six weeks. Participants who are treatment responders may be
asked to return approximately 3 months after completing treatment for a follow-up
assessment.
Preliminary hypotheses: 1) AMP will be acceptable to youth and families and feasible to
administer; 2) Youth receiving AMP will demonstrate decreases in threat bias and OCD symptom
severity.
significant concurrent and long-term risk to affected youth. Although empirically supported
psychosocial and pharmacological treatments for OCD exist, many children and their families
are not able to adequately access these treatments or derive only partial benefit from them.
Such findings highlight the importance of developing more effective treatment options which
have the potential to be widely accessible to OCD youth.
The investigators are proposing to test a computerized attention modification program, AMP,
in six youth with OCD in an open case series to gather information regarding protocol
acceptability, feasibility and preliminary efficacy. This phase includes the development and
refinement of stimuli selection procedures, behavior avoidance task, EEG protocol, and AMP
parameters for use with children.
Following ascertainment of study eligibility, participants will undergo a baseline
assessment consisting of a clinical interview, neurocognitive assessments, EEG, attention
bias assessment, and self report questionnaires. Study participants will then receive 12
sessions of AMP treatment over the course of three weeks. All youngsters and their families
will be reassessed at treatment endpoint (week 4). Participation will take a total of about
24 hours over the course of six weeks. Participants who are treatment responders may be
asked to return approximately 3 months after completing treatment for a follow-up
assessment.
Preliminary hypotheses: 1) AMP will be acceptable to youth and families and feasible to
administer; 2) Youth receiving AMP will demonstrate decreases in threat bias and OCD symptom
severity.
Inclusion Criteria:
- Youth ages 8 - 17
- Primary DSM-IV diagnosis of OCD as determined by Anxiety Disorders Interview Schedule
(ADIS-IV) Child/Parent version
- Child Yale-Brown Obsessive Compulsive Scale (CYBOCS) score > 15
- Medication free or on stable medication for six weeks prior to study entry
- Informed parental consent and child assent. Parents must agree to their child's
participation in this protocol. Parents will be asked to fill out self-report
questionnaires and participate in assessments that will provide us with more
information about their child, however parents are not considered "participants"
within this protocol, as all treatment is targeted toward their child.
Exclusion Criteria:
- DSM-IV depressive disorder, bipolar disorder, PTSD, substance abuse/dependence,
conduct disorder, PDD, schizophrenia, or mental retardation
- Concurrent psychosocial treatment for OCD
- IQ < 80
- Youngsters with other comorbid disorders (e.g., anxiety, ADHD, ODD, tic disorder)
will be eligible as long as these disorders are secondary to OCD in terms of severity
and impairment and do not require immediate treatment initiation.
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