Alglucosidase Alfa Pompe Safety Sub-Registry

Inclusion Criteria:

- The patient must be enrolled in the Pompe Registry;

- Provide a signed patient information and authorization form;

- Have a confirmed diagnosis of Pompe disease (confirmation of diagnosis is defined as
documented GAA enzyme deficiency from any tissue source and/or documentation of 2 GAA
gene mutations);

- Be naïve to and plan to be treated with alglucosidase alfa at or prior to enrollment,
or are being treated with alglucosidase alfa.

Exclusion Criteria:

- Patients will be excluded if they have received an investigational drug (excluding
alglucosidase alfa) within 30 days prior to signing a Safety Sub-Registry Patient
Information and Authorization form, or if they are taking or plan to take any
investigational product while enrolled in the Safety Sub-Registry.