An Extension Study of NKTR-102 in Cancer Patients Previously Enrolled in NKTR-102 Studies



Status:Completed
Conditions:Breast Cancer, Colorectal Cancer, Ovarian Cancer, Cancer, Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:5/3/2018
Start Date:October 2011
End Date:November 2017

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An Open-Label, Multicenter, Extension Study of NKTR-102 in Subjects Previously Enrolled in NKTR-102 Studies

The study objective of this open label, multicenter study is to provide access to NKTR-102
treatment to subjects previously enrolled in a NKTR-102 study who are without signs of
disease progression since receiving NKTR-102.

In addition the study will evaluate the safety of continued exposure to NKTR-102, observe
disease status and survival status in subjects receiving NKTR-102, and evaluate the efficacy
of NKTR-102 in subjects with advanced or metastatic solid tumors.


Inclusion:

1. Received prior treatment with NKTR-102

2. Free of disease progression since receiving NKTR-102

3. Adequate bone marrow and organ function

4. Treatment with NKTR-102 in the extension study to begin within 8 weeks after receipt
of their of last dose of NKTR-102

5. Agree to use adequate contraception

Exclusion:

1. Treatment with other anti-cancer therapy between the last dose of NKTR-102 in the
prior study and before first dose of NKTR-102 in the extension study

2. A toxicity that requires a 3rd dose reduction after taking NKTR-102 or are scheduled
to receive a dose < 70 mg/m2 upon entry into this study

3. Pregnancy or lactation
We found this trial at
6
sites
Minneapolis, Minnesota 55455
(612) 625-5000
Univ of Minnesota With a flagship campus in the heart of the Twin Cities, and...
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1600 Divisadero Street
San Francisco, California 94115
888.689.8273
Principal Investigator: Pamela Munster, MD
Phone: 415-885-7605
UCSF Helen Diller Family Comprehensive Cancer Center UCSF’s long tradition of excellence in cancer research...
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San Francisco, CA
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Bruxelles,
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Cleveland, Ohio 44106
Principal Investigator: Smitha Krishnamurthi, MD
Phone: 216-844-5467
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Cleveland, OH
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1441 Eastlake Ave
Los Angeles, California 90033
(323) 865-3000
Principal Investigator: Anthony El-Khoueiry, MD
U.S.C./Norris Comprehensive Cancer Center The USC Norris Comprehensive Cancer Center, located in Los Angeles, is...
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Los Angeles, CA
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Whittier, California 90603
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Whittier, CA
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