A Phase 4, Open-label Study to Assess the Feasibility and Efficacy on Motor and Non-motor Symptoms of Switching From Pramipexole or Ropinirole to Rotigotine Transdermal Patch in Subjects With Advanced Idiopathic Parkinson's Disease

Inclusion Criteria:

- Subject has idiopathic Parkinson's Disease of more than 3 years duration, as defined
by the cardinal sign, bradykinesia, plus the presence of at least 1 of the following:
resting tremor, rigidity, impairment of postural reflexes and is without any other
known or suspected cause of Parkinsonism

- Subject has motor fluctuations

- Subject is not satisfactorily controlled following the investigator´s assessment on a
total daily dose of Pramipexole or Ropinirole

- Subject has sleep disturbance or early morning motor impairment

- Subject has experienced nocturia for at least 3 nights within 7 days prior to the
Baseline Visit

- Subject is taking L-dopa in combination with Benserazide or Carbidopa and has been on
a stable dose of L-dopa for at least 28 days prior to the Baseline Visit

Exclusion Criteria:

- Subject has had therapy with Tolcapone or Budipine

- Subject is receiving therapy with one of the following drugs either concurrently or
within 28 days prior to Baseline (Visit 2): alpha-methyl dopa, metoclopramide,
reserpine, neuroleptics, monoamine oxidase A (MAO-A) inhibitors, methylphenidate, or
amphetamine

- Subject has a history of symptomatic (not asymptomatic) orthostatic hypotension in
the 6 months prior to Baseline (Visit 2)

- Subject has a history of significant skin hypersensitivity to adhesive or other
transdermal preparations, or recent unsolved contact dermatitis

- Subject has a history of seizures or stroke within 1 year, or a history of myocardial
infarction within the last 6 months prior to enrollment

- Subject is pregnant or nursing, or is of childbearing potential but (i) not
surgically sterile or (ii) not using adequate birth control methods (including at
least 1 barrier method) or (iii) not sexually abstinent or (iv) not at least 2 years
postmenopausal

- Subject has a previous diagnosis of narcolepsy, sleep apnea syndrome, restless legs
syndrome, or periodic limb movement disorder