Diffusion Tensor Imaging to Assess the Functional Outcomes of Adults With Cervical Spinal Cord Injuries



Status:Withdrawn
Conditions:Hospital, Women's Studies
Therapuetic Areas:Other, Reproductive
Healthy:No
Age Range:18 - 65
Updated:5/5/2018
Start Date:January 2014
End Date:January 2016

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Trial Summary
Trial Overview
Inclusion Criteria

Diffusion Tensor MRI to Assess Subacute Functional Outcomes in Patients With Acute Cervical Spinal Cord Injuries

Acute changes in axial diffusivity will correlate with the severity of injury in patients
that suffer an acute spinal cord injury.

Diffusion tensor imaging (DTI) parameters will correlate with severity of spinal cord injury
in SCI patients as seen in rodent models. We will test whether the quantitative decrease in
axial (λ║) diffusivity (a biomarker of axonal injury), will predict long-term functional
outcomes for patients with a SCI.

Specific Aim: To examine patients after an acute SCI using DTI and to correlate the extent of
acute decrease in λ║ with the presenting ASIA motor score and long-term functional outcome of
the patient.

Inclusion Criteria:

- 18-65 years of age

- Cervical spinal cord injury

- physically and mentally willing to comply with imaging

- lives in immediate area with no plans to relocate

Exclusion Criteria:

- Associated moderate to severe head injury

- Active malignancy

- Previous spinal cord injury

- pregnancy

- inability to tolerate MRI scanning
We found this trial at
1
site
Washington University School of Medicine
660 S Euclid Ave
Saint Louis, Missouri 63110
(314) 362-5000
Washington University School of Medicine Washington University Physicians is the clinical practice of the School...
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mi
from
Saint Louis, MO
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