Safety Study of Inhaled Saline in Acute Lung Injury
| Status: | Completed |
|---|---|
| Conditions: | Cardiology, Hospital, Pulmonary |
| Therapuetic Areas: | Cardiology / Vascular Diseases, Pulmonary / Respiratory Diseases, Other |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 8/15/2015 |
| Start Date: | October 2013 |
| End Date: | December 2015 |
| Contact: | Richard A Oeckler, M.D., Ph.D. |
| Email: | oeckler.richard@mayo.edu |
| Phone: | 507-284-2158 |
Inhaled Hypertonic Saline for the Treatment of Acute Lung Injury
To determine if an inhaled hypertonic saline solution has any effect on lung function in
patients with acute respiratory distress syndrome (ARDS).
patients with acute respiratory distress syndrome (ARDS).
Hypertonic Saline (HS) aerosols have proven efficacious mucolytics in patient with cystic
fibrosis and are well tolerated in that population. Safety concerns in mechanically
ventilated patients with ARDS center primarily on HS's effects on lung water distribution
(intra vs. extra alveolar) and on airway reactivity. For that reason we plan a small
feasibility trial with narrowly focused physiologic endpoints, namely to measure the effects
of a single 5ml dose of 7% Saline aerosol on blood gas tensions, hemodynamics and the static
and dynamic properties of the relaxed respiratory system. This narrowly scoped study is to
lay the foundation for a larger multicenter intervention trial.
fibrosis and are well tolerated in that population. Safety concerns in mechanically
ventilated patients with ARDS center primarily on HS's effects on lung water distribution
(intra vs. extra alveolar) and on airway reactivity. For that reason we plan a small
feasibility trial with narrowly focused physiologic endpoints, namely to measure the effects
of a single 5ml dose of 7% Saline aerosol on blood gas tensions, hemodynamics and the static
and dynamic properties of the relaxed respiratory system. This narrowly scoped study is to
lay the foundation for a larger multicenter intervention trial.
Inclusion Criteria:
- Study participants will include consenting adult patients (age > 18), who had been
intubated and mechanically ventilated for <72 hours and meet international consensus
criteria for ARDS.
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