Drug Delivery Via Pressurized Metered-dose Inhaler and Valved Holding Chamber in Asthmatic Children: Determination of Delivered Dose Following Coordinated and Uncoordinated Use

Inclusion Criteria:

- • Asthmatic children between the ages of 5 and 8 followed at Arkansas Children's
Hospital.

- The subjects must be available to complete the study.

- The subject's parent(s) and/or the subject's legal guardian must provide written
informed consent to participate in the study.

- The subject must provide assent when older than 7 years old.

- The subjects should have used a pMDI VHC previously and be able to use a VHC
with mouthpiece.

- The subjects should have been prescribed fluticasone or another inhaled
corticosteroid delivered via a pMDI VHC combination.

- Clinically stable asthma.

- Cooperative, i.e., subject should be able to follow and understand instructions.

- The subject must satisfy the study investigator about his/her fitness to
participate in the study.

Exclusion Criteria:

- Clinically significant respiratory disease in the previous 4 weeks.

- Participation in any other clinical trial in the previous 4 weeks.

- Lack of cooperation, subject cannot follow and understand instructions.