Randomized Trial to Assess PO Versus IV Antibiotics

Not provided here. Details listed above.

Inclusion Criteria:

1. Patients with any fractures of any bone at or proximal to and including the
tarsal/metatarsal joint (Lisfranc) or proximal to the carpal joints (includes distal
radius fractures), excluding the spine, treated with any type of internal fixation, or

2. Patients undergoing fusion of any bone at or proximal to and including the subtalar
joint or radial carpal joint, (excluding the spine) that develop a post op wound
infection at any time.

3. Patients diagnosed with a wound infection of the study injury, defined as patients
with at least one of the following:

1. Deep culture positive after operative debridement.

2. Cultures positive in thio only after operative debridement.

3. Negative culture after operative debridement if wound infection meets the Center
for Disease control and Prevention (CDC) criteria.

4. Patients who are English or Spanish competent.

5. Patients aged 18 - 84.

6. Patients with bacteria susceptible to both PO and IV antibiotics.

7. Patients able to be treated for their infection at the METRC facility for at least 12
months following definitive surgical procedure

8. Patients may have multiple eligible study-eligible injuries.

9. Patients may have temporary external fixation prior to definitive fixation.

10. Patients may have received antibiotics prior to operative wound debridement.

11. Patient is able to obtain study medication(s).

12. Patient may be pregnant at the time of screening.

Exclusion Criteria:

1. Patients who have high risk of amputation of the study limb (based on opinion of the
initial managing physician).

2. Patients undergoing treatment with any other investigational therapy within the month
preceding implantation or planned within the 12 months following implantation.

3. Patients with history of chronic infection at the site of study injury, defined as:

patients with chronic osteomyelitis identified by radiographic erosion or sequestrum;
or patients with more than one instance of surgical treatment of infection and
approximately 6 week course of antibiotics.

4. Patients with pathological fractures; a known history of Paget's disease.

5. Patients for whom the definitive treatment of the study injury was an external
fixator.

6. Patients who are currently on Selective Serotonin Reuptake Inhibitor (SSRI) medication
(e.g. Zoloft, Prozac, Celexa), and bacteria is MRSA

7. Patients with cultures positive in thio only.

8. Patients who are incarcerated or who have unstable housing situations due to concerns
regarding ability to receive home care, adherence phone calls, and maintain follow up.
.

9. Patients or designated proxy who are unwilling to provide consent.

10. Patients with a history of IV drug use who in the investigator's opinion are
unsuitable candidates for IV therapy.

11. Patients likely to have severe problems maintaining follow-up, including patients
diagnosed with a severe psychiatric conditions, patients who live too far outside the
hospital's catchment area.

12. Patients with traumatic brain injury or who are intellectually challenged and who lack
adequate family support to ensure adherence to the protocol.

13. Patients unable to swallow oral medications or without adequately functioning GI
tract.

14. Patients who, based upon the clinical judgment of the treating clinician, are NOT
equally suited for treatment with either oral or intravenous antibiotics (i.e., those
for whom there is a clinical treatment preference).