A Study of Brentuximab Vedotin in Adults Age 60 and Above With Newly Diagnosed Hodgkin Lymphoma (HL)
| Status: | Recruiting |
|---|---|
| Conditions: | Lymphoma |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 60 - Any |
| Updated: | 4/3/2019 |
| Start Date: | October 2012 |
| End Date: | July 2021 |
| Contact: | Seattle Genetics Trial Information Support |
| Email: | clinicaltrials@seagen.com |
| Phone: | 866-333-7436 |
A Phase 2 Open-label Study of Brentuximab Vedotin in Front-line Therapy of Hodgkin Lymphoma (HL) in Adults Age 60 and Above
This is an open-label, multicenter, phase 2 clinical trial designed to evaluate the efficacy
and safety of brentuximab vedotin as a single-agent (Part A) and in combination with
dacarbazine (Part B), bendamustine (Part C), or nivolumab (Part D) in front-line therapy of
HL in adults age 60 and above.
and safety of brentuximab vedotin as a single-agent (Part A) and in combination with
dacarbazine (Part B), bendamustine (Part C), or nivolumab (Part D) in front-line therapy of
HL in adults age 60 and above.
Inclusion Criteria:
- Histopathologically-confirmed diagnosis of classical Hodgkin lymphoma
- Ineligible for or have declined initial conventional combination chemotherapy
- Measurable disease of at least 1.5 cm as documented by radiographic technique
- ECOG performance status less than or equal to 3
Exclusion Criteria:
- Symptomatic neurologic disease compromising instrumental activities of daily living or
requiring medication
- Concurrent use of other investigational agents
- Chemotherapy, radiotherapy, biologics, and/or other treatment with immunotherapy not
completed 4 weeks prior to first dose of study drug
We found this trial at
24
sites
Round Rock, Texas 78665
Principal Investigator: Vivian Cline-Burkhardt, MD
Phone: 281-863-6658
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1720 2nd Ave S
Birmingham, Alabama 35233
Birmingham, Alabama 35233
(205) 934-4011
Principal Investigator: Amitkumar Mehta, MD
Phone: 205-996-8400
University of Alabama at Birmingham The University of Alabama at Birmingham (UAB) traces its roots...
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601 Elmwood Avenue
Rochester, New York 14642
Rochester, New York 14642
(585) 275-5830
Principal Investigator: Jonathan Friedberg, MD
Phone: 585-273-3903
James P. Wilmot Cancer Center at University of Rochester Medical Center The Wilmot Cancer Center...
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Albany, New York 12206
Principal Investigator: Lawrence Garbo, MD
Phone: 281-863-6658
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Aurora, Colorado 80012
Principal Investigator: John Burke, MD
Phone: 281-863-6658
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Bedford, Texas 76022
Principal Investigator: Henrik Illum, MD
Phone: 281-863-6658
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6410 Rockledge Dr #660
Bethesda, Maryland 20817
Bethesda, Maryland 20817
(301) 571-0019
Principal Investigator: Ralph Boccia, MD
Phone: 301-571-2016
Center for Cancer & Blood Disorders Widely recognized for its compassionate, expert care, the Center...
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Blacksburg, Virginia 24060
Principal Investigator: Jerome Goldschmidt, MD
Phone: 281-863-6658
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Burbank, California 91505
Principal Investigator: Ravi M. Shankar, MD
Phone: 818-748-4726
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Denton, Texas 76210
Principal Investigator: Charles Kurkul, MD
Phone: 940-382-1022
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1500 East Duarte Road
Duarte, California 91010
Duarte, California 91010
626-256-HOPE (4673)
Principal Investigator: Matthew Mei, MD
Phone: 626-256-4673
City of Hope National Medical Center City of Hope is dedicated to making a difference...
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Eugene, Oregon 97401
Principal Investigator: Christopher Yasenchak, MD
Phone: 281-863-6658
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8503 Arlington Blvd., Ste. 400
Fairfax, Virginia 22031
Fairfax, Virginia 22031
(703) 280-5390
Principal Investigator: Dipti Patel-Donnelly, MD
Phone: 281-863-6658
Virginia Cancer Specialists, PC Now the world's most advanced cancer treatment capabilities can be found...
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Fort Worth, Texas 76104
Principal Investigator: Robert L. Ruxer, MD
Phone: 281-863-6658
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Greenville, South Carolina 29605
Principal Investigator: Jeffrey Giguere
Phone: 281-863-6658
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Longview, Texas 75601
Principal Investigator: Matei Socoteanu, MD
Phone: 281-863-6658
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Minneapolis, Minnesota 55405
Principal Investigator: Timothy Larson, MD
Phone: 281-863-6658
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Niles, Illinois 60714
Principal Investigator: Leonard Klein, MD
Phone: 281-863-6658
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Omaha, Nebraska 68114
Principal Investigator: Ralph Hauke, MD
Phone: 281-863-6658
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1250 E. Marshall St.
Richmond, Virginia 23298
Richmond, Virginia 23298
(804) 828-9000
Principal Investigator: Victor Yazbeck, MD
Phone: 804-628-1909
Virginia Commonwealth University Medical Center The Virginia Commonwealth University Health System is an urban, comprehensive...
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Sandy Springs, Georgia 30341
Principal Investigator: Rodolfo Bordoni, MD
Phone: 770-496-9400
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Seattle, Washington 98104
Principal Investigator: John Pagel
Phone: 206-215-1426
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Tualatin, Oregon 97062
Principal Investigator: Kathryn Kolibaba, MD
Phone: 281-863-6658
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Tucson, Arizona 85704
Principal Investigator: Donald Brooks, MD
Phone: 281-863-6658
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