Protocols for Improved in Vitro Fertilization (IVF) Outcomes
| Status: | Archived |
|---|---|
| Conditions: | Women's Studies, Infertility |
| Therapuetic Areas: | Reproductive |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 7/1/2011 |
Protocol Evaluation for Improved In Vitro Fertilization Outcomes
Many infertile patients have a decreased chance of becoming pregnant when using in vitro
fertilization (IVF). For these patients, many different treatments are available, but none
of them have been shown to be better than the others. We are testing which of three
different treatments are better than the others. Patients who are expected to have a
decreased response to ovarian stimulation will be randomized to either a microflare
protocol, an antagonist protocol, or a demi-halt protocol.
Infertile patients with an anticipated poor response to ovarian stimulation will be
randomized to one of three different protocols in their upcoming IVF cycle. Each of the
protocols will be performed as is the standard of care with the addition of serum evaluation
during the course of the stimulation as well as follicular fluid analysis which is obtained
as a byproduct of the oocyte retrieval. Chart review will be performed to collect
background characteristics (including age, ethnicity, previous fertility treatment),
treatment response (such as oocyte number, embryo grade, embryo quality), and pregnancy
outcome (such as miscarriage, singleton pregnancy, or higher-order multiple pregnancy).
Statistical analysis will be performed to determine if one protocol leads to higher
pregnancy rates and multivariate analysis will be performed to determine potential etiologic
variables.
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