Pioglitazone for the Treatment of Bipolar Depression

The study is a double-blind, placebo-controlled 8-week trial of pioglitazone, either as
monotherapy or adjunctive to a mood stabilizer, for the acute relief of bipolar depression.
The enrollment goal is 80 subjects (40 patients each in the pioglitazone treatment group and
the placebo treatment group).

Screening Phase: Patients who have been prescribed a mood stabilizer for > 4 weeks and are
on a therapeutic dose will proceed directly to the Screening Visit. For situations in which
the patient prefers to be taking a mood stabilizer or where the treating psychiatrist feels
it is clinically necessary, a mood stabilizer (lithium, divalproex, carbamazepine,
lamotrigine, olanzapine, quetiapine, risperidone, aripiprazole, ziprasidone or lurasidone)
will be initiated (see Mood Stabilizer Initiation section below). For this set of patients
who do begin a mood stabilizer, the Screening Phase may last up to 8 weeks. Otherwise,
subjects who do not come in on a mood stabilizer will proceed directly to screening.

Double-Blind, Placebo-Controlled Study Period (Week 1 to Week 8): Patients who meet
inclusion/exclusion criteria will be randomized to study treatment at the
baseline/randomization visit within 30 days of the screening visit. The efficacy and safety
assessments will be carried out at baseline/randomization and then weekly or every two weeks
for a total of 8 weeks.

Inclusion Criteria:

- Be male or female >= 18 years of age

- Diagnostic and Statistical Manual-IV (DSM-IV) diagnosis of bipolar disorder (type I,
II, or NOS)

- Currently depressed as confirmed by the Mini-International Neuropsychiatric Interview
(M.I.N.I.)-Plus at the screening visit

- Inventory of Depressive Symptoms total score > 25 or Quick Inventory of Depressive
Symptomatology-Self-Report (QIDS-SR16) > 11 at study baseline

- Women of childbearing potential (not surgically sterile or 2 years postmenopausal),
must use a medically accepted method of contraception and must agree to continue use
of this method for the duration of the study and for 30 days after participation in
the study. Acceptable methods of contraception include barrier method with
spermicide, abstinence, intrauterine device (IUD), or steroidal contraceptive (oral,
transdermal, implanted, and injected) in conjunction with a barrier method.

Exclusion Criteria:

- Pregnant or breast feeding

- Unstable or inadequately treated medical illness as judged by the investigator

- Severe personality disorder

- Serious suicidal risk as judged by the investigator or having a score ≥ 4 on
Montgomery Asberg Depression Rating Scale (MADRS) item number 10 (suicidal thoughts)
at screening or baseline

- Known history of intolerance or hypersensitivity to pioglitazone

- Treatment with pioglitazone in the 3 months prior to randomization

- Dependence on alcohol or drugs (other than nicotine) in the 3 months prior to study
entry

- Currently taking insulin or rosiglitazone.

- Diagnosed with dementia

- Acute Mania as defined by a Young Mania Rating Scale (YMRS) score > 15

- Diagnosed with heart failure

- Transaminase elevation >2.5 times the upper limit of normal

- Presence of renal impairment (eg. creatinine > 1.5)

- History of bladder carcinoma

- Fasting blood glucose >150 mg/dL and Hb A1c> 7%; participants meeting these criteria
will be referred to an endocrinologist or their primary care physician for a diabetes
evaluation and education.

- Receiving acute series of electroconvulsive therapy