Genetic Basis of Mitral Valve Prolapse
| Status: | Recruiting |
|---|---|
| Conditions: | Cardiology, Neurology |
| Therapuetic Areas: | Cardiology / Vascular Diseases, Neurology |
| Healthy: | No |
| Age Range: | 18 - 80 |
| Updated: | 4/17/2018 |
| Start Date: | January 1999 |
| End Date: | December 2020 |
| Contact: | Susan Slaugenhaupt, PhD |
| Email: | slaugenhaupt@chgr.mgh.harvard.edu |
| Phone: | 6176433217 |
The investigators have successfully identified two novel genetic loci for MVP on chromosomes
11 and 13 and are searching for altered genes in these regions. This requires recruiting
large families who may have MVP linked to these or other chromosomes; and obtaining DNA
samples from 1,000-1,500 individually affected patients to study the relation between DNA
markers throughout the genome and MVP. It is our expectation that the results of this study
will lead to the discovery of gene(s) responsible for MVP. This will lead to improved
understanding of the disease and, in turn, improved ability to treat and prevent progression
in genetically susceptible individuals.
11 and 13 and are searching for altered genes in these regions. This requires recruiting
large families who may have MVP linked to these or other chromosomes; and obtaining DNA
samples from 1,000-1,500 individually affected patients to study the relation between DNA
markers throughout the genome and MVP. It is our expectation that the results of this study
will lead to the discovery of gene(s) responsible for MVP. This will lead to improved
understanding of the disease and, in turn, improved ability to treat and prevent progression
in genetically susceptible individuals.
This is a genome-wide association study.
Inclusion Criteria:
- Mitral valve prolapse
Exclusion Criteria:
- Other mitral valve diseases
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