Docetaxel, Gemcitabine and Pazopanib as Treatment for Soft Tissue Sarcoma
| Status: | Completed |
|---|---|
| Conditions: | Cancer |
| Therapuetic Areas: | Oncology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 10/14/2017 |
| Start Date: | October 2012 |
| End Date: | April 2015 |
Phase I/II Study of the Combination of Docetaxel, Gemcitabine and Pazopanib for Neoadjuvant Treatment of Patients With Operable Soft Tissue Sarcoma
Chemotherapy treatment with docetaxel and gemcitabine is a standard treatment for patients
with soft tissue sarcoma. This study is designed to explore whether the addition of tyrosine
kinase inhibitor pazopanib enhances the anticancer effect of the chemotherapy drugs.
The Phase I component of this study is designed to determine the maximum tolerated dose of
pazopanib when given with docetaxel and gemcitabine. The Phase II component is designed to
determine the overall response rate of the combination of docetaxel, gemcitabine and
pazopanib prior to surgical resection in patients with soft tissue sarcoma.
with soft tissue sarcoma. This study is designed to explore whether the addition of tyrosine
kinase inhibitor pazopanib enhances the anticancer effect of the chemotherapy drugs.
The Phase I component of this study is designed to determine the maximum tolerated dose of
pazopanib when given with docetaxel and gemcitabine. The Phase II component is designed to
determine the overall response rate of the combination of docetaxel, gemcitabine and
pazopanib prior to surgical resection in patients with soft tissue sarcoma.
Inclusion Criteria:
- 18 years or older
- chemotherapy naive, histologically high grade soft tissue sarcoma that is considered
to be operable
- tumor greater than 5 cm in longest dimension
- life expectancy of at least 6 months
- Zubrod performance status of 0-2
- signed informed consent
- adequate bone marrow function defined by:
1. absolute peripheral granulocyte count of >1500 cells/mm^3
2. hemoglobin >8.0 g/dl
3. platelet count >100,000/mm^3
4. absence of a regular red blood cell transfusion requirement
- adequate hepatic function defined by:
1. total bilirubin <1.5 x upper limit of normal (ULN)
2. AST, ALT and alkaline phosphatase all not more than 2.5 x ULN
- adequate renal function defined by:
1. serum creatinine <1.5 x ULN
- negative pregnancy test for women of child bearing potential
- willingness to use effective contraception while on treatment and for 3 months
thereafter
Exclusion Criteria:
- Multiple metastases (patients with 5 or fewer oligometastases that could be resectable
are eligible)
- Pregnant women or nursing mothers
- concurrent chemotherapy or radiation therapy
- severe medical problems (at the discretion of the investigator)
- history of severe hypersensitivity reaction to docetaxel or other drugs formulated
with polysorbate 80
- symptomatic brain metastases
- cirrhosis
- dermatofibrosarcoma protuberans (DFSP), embryonal rhabdomyosarcoma or alveolar soft
part sarcoma (ASPS)
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