Neurophysiologic Correlates of Hypersomnia
| Status: | Completed |
|---|---|
| Conditions: | Depression, Insomnia Sleep Studies, Major Depression Disorder (MDD), Psychiatric, Bipolar Disorder |
| Therapuetic Areas: | Psychiatry / Psychology, Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 18 - 60 |
| Updated: | 12/26/2018 |
| Start Date: | November 2012 |
| End Date: | June 2018 |
Neurophysiologic Correlates of Hypersomnia: a High Density EEG Investigation
The goal of this project is to examine the neurophysiology of hypersomnia during sleep and
wakefulness, to identify biomarkers for excessive sleepiness in neuropsychiatric disorders,
and pilot acoustical slow wave induction during sleep in patients with hypersomnolence, to
determine if this decreases daytime sleepiness in these patients. The primary study
hypotheses are that individuals with hypersomnolence will have reduced slow wave activity
(SWA) during sleep and increased waking theta/alpha activity during wake in specific brain
regions. A secondary hypothesis is that acoustical slow wave induction in hypersomnolent
patients will increase SWA during sleep, reduce theta/alpha activity during wake, and improve
subjective sleepiness.
wakefulness, to identify biomarkers for excessive sleepiness in neuropsychiatric disorders,
and pilot acoustical slow wave induction during sleep in patients with hypersomnolence, to
determine if this decreases daytime sleepiness in these patients. The primary study
hypotheses are that individuals with hypersomnolence will have reduced slow wave activity
(SWA) during sleep and increased waking theta/alpha activity during wake in specific brain
regions. A secondary hypothesis is that acoustical slow wave induction in hypersomnolent
patients will increase SWA during sleep, reduce theta/alpha activity during wake, and improve
subjective sleepiness.
Inclusion Criteria:
- Meet Diagnostic and Statistical Manual edition IV criteria for neuropsychiatric
disorders enumerated in study population description
Exclusion Criteria:
Exclusionary criteria for all subjects will include: evidence of a clinically significant
sleep disorder that would cause hypersomnolence (e.g. moderate to severe obstructive sleep
apnea, restless legs syndrome, shift-work sleep disorder), history of significant head
trauma or loss of consciousness > 30 minutes; current smoking of more than 15 cigarettes
per day; >3 caffeinated beverages per day; significant neurologic or medical illness;
active drug/alcohol abuse/dependence (within 6 months of enrollment), women who are
pregnant, <6 months post-partum, nursing or planning to become pregnant during the study;
left-handedness (due to effects on sleep topography); and imminent risk for self-harm or
suicide.
We found this trial at
1
site
Madison, Wisconsin 53719
Phone: 608-232-3333
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