Study of LGX818 and Cetuximab or LGX818, BYL719, and Cetuximab in BRAF Mutant Metastatic Colorectal Cancer



Status:Active, not recruiting
Conditions:Colorectal Cancer, Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:9/7/2018
Start Date:November 2012
End Date:July 31, 2019

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A Phase lb/II Multi-center, Open-label, Dose Escalation Study of LGX818 and Cetuximab or LGX818, BYL719, and Cetuximab in Patients With BRAF Mutant Metastatic Colorectal Cancer

This study will assess the safety and efficacy of LGX818 when combined with cetuximab or
combined with cetuximab and BYL719 in patients with BRAF mutant metastatic colorectal cancer


Inclusion Criteria:

- Metastatic colorectal cancer

- Progression after at least one prior standard of care regimen or be intolerant to
irinotecan-based regimens

- Life expectancy ≥ 3 months

- ECOG performance status ≤ 2

Exclusion Criteria:

- Symptomatic or untreated leptomeningeal disease

- Symptomatic brain metastasis

- Patients with clinically manifested diabetes

- Acute or chronic pancreatitis

- Clinically significant cardiac disease

Other protocol-defined inclusion/exclusion criteria may apply.
We found this trial at
11
sites
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from
Columbus, OH
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from
Boston, MA
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from
Hackensack, NJ
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from
Los Angeles, CA
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mi
from
Los Angeles, CA
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Nashville, Tennessee 37203
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from
Nashville, TN
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Nashville, Tennessee 37232
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from
Nashville, TN
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New Haven, Connecticut 06520
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from
New Haven, CT
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from
New York, NY
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from
Parkville,
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from
Salt Lake City, UT
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