Effects of Dexmedetomidine on Activity in the Subthalamic Nucleus
| Status: | Completed |
|---|---|
| Conditions: | Parkinsons Disease |
| Therapuetic Areas: | Neurology |
| Healthy: | No |
| Age Range: | 18 - 85 |
| Updated: | 12/10/2017 |
| Start Date: | November 2012 |
| End Date: | June 2015 |
Effects of Dexmedetomidine on Neuronal Activity in the Subthalamic Nucleus During Deep Brain Stimulation (DBS) Electrode Implantation Surgery
The purpose of this research study is to find out whether dexmedetomidine changes brain cell
activity in the subthalamic nucleus (STN).
activity in the subthalamic nucleus (STN).
In order to find whether dexmedetomidine is optimal for sedation during Deep brain
stimulation surgery, we will measure the electrical activity in the STN during Deep brain
stimulation surgery, and measure how this activity is changed during administration of
Dexmedetomidine. We hypothesize that dexmedetomidine does not change the firing rate and
pattern in the STN.
stimulation surgery, we will measure the electrical activity in the STN during Deep brain
stimulation surgery, and measure how this activity is changed during administration of
Dexmedetomidine. We hypothesize that dexmedetomidine does not change the firing rate and
pattern in the STN.
Inclusion Criteria:
- Patients scheduled to undergo bilateral STN electrode implantation surgery with
Micro-electrode recording for the treatment of Parkinson's disease.
Exclusion Criteria:
- Hypersensitivity to dexmedetomidine
- Bradycardia: Sinus rhythm slower than 50 bpm
- Known or suspected obstructive sleep apnea
- Suspected difficult intubation
- Pregnancy
- Under 18 years of age or over 85 years of age
- Cognitive disability impairing understanding the experiment or signing the informed
consent form
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