Parallel-Group Study to Assess the Effect of Rasagiline on Cognition in Patients With Parkinson's Disease



Status:Completed
Conditions:Parkinsons Disease
Therapuetic Areas:Neurology
Healthy:No
Age Range:45 - 80
Updated:4/21/2016
Start Date:November 2012
End Date:January 2015

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A 24-Week, Multicenter, Randomized, Double-blind, Placebo-Controlled, Add-on, Parallel-Group Study to Assess the Effect of Rasagiline on Cognition in Patients With Parkinson's Disease

This is a 24-week, multicenter, randomized, double-blind, placebo-controlled, add-on,
parallel-group study to evaluate the effect of rasagiline on cognitive function in adults
with mild cognitive impairment (MCI) in Parkinson's disease (PD-MCI).


Inclusion Criteria:

1. Nondemented man or woman 45 through 80 years of age with idiopathic Parkinson's
disease (PD) based on the United Kingdom (UK) Parkinson's Disease Society Brain Bank
Clinical Diagnostic Criteria

2. Hoehn and Yahr stage ≥ 1 (symptoms on only 1 side of the body) with treatment and ≤ 3
(mild-to-moderate bilateral disease; some postural instability; physically
independent)

3. Mild cognitive impairment in Parkinson's disease based on the Movement Disorder
Society (MDS) Task Force Diagnostic Criteria and the Montreal Cognitive Assessment
(MoCA) rating scale (range, 20-25, inclusive)

4. Medically stable outpatient, based on the investigator's judgment

5. The patient is on a stable dopaminergic medication regimen for ≥ 30 days before
entering the study (Screening/Baseline Visit)

6. Other inclusion criteria apply; please contact the site for more information

Exclusion Criteria:

1. Clinically relevant history of vascular disease (eg, stroke)

2. History of melanoma

3. History of deep brain stimulation (DBS)

4. Impaired hepatic function, based on the investigator's judgment

5. Psychosis or is receiving antipsychotic treatment

6. Clinically significant or unstable medical or surgical condition that may preclude
safe and complete study participation, based on the investigator's judgment

7. Other exclusion criteria apply; please contact the site for more information
We found this trial at
41
sites
Asheville, North Carolina
302
mi
from 43215
Asheville, NC
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515
mi
from 43215
Albany, NY
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436
mi
from 43215
Atlanta, GA
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Baton Rouge, Louisiana
802
mi
from 43215
Baton Rouge, LA
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Birmingham, Alabama
492
mi
from 43215
Birmingham, AL
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Boca Raton, Florida
955
mi
from 43215
Boca Raton, FL
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Boston, Massachusetts
643
mi
from 43215
Boston, MA
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Boston, Massachusetts
643
mi
from 43215
Boston, MA
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Chicago, Illinois
274
mi
from 43215
Chicago, IL
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Chicago, Illinois
274
mi
from 43215
Chicago, IL
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Chicago, Illinois
274
mi
from 43215
Chicago, IL
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Commack, New York
515
mi
from 43215
Commack, NY
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Danbury, Connecticut
510
mi
from 43215
Danbury, CT
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1162
mi
from 43215
Denver, CO
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Englewood, Colorado
1163
mi
from 43215
Englewood, CO
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Irvine, California
1960
mi
from 43215
Irvine, CA
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Jacksonville, Florida
670
mi
from 43215
Jacksonville, FL
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Kansas City, Kansas
620
mi
from 43215
Kansas City, KS
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Kingston, New York
489
mi
from 43215
Kingston, NY
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La Jolla, California
1953
mi
from 43215
La Jolla, CA
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LaCrosse, Wisconsin
396
mi
from 43215
LaCrosse, WI
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Las Vegas, Nevada
1756
mi
from 43215
Las Vegas, NV
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Lexington, Kentucky
154
mi
from 43215
Lexington, KY
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Long Beach, California
1977
mi
from 43215
Long Beach, CA
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Manchester, Connecticut
562
mi
from 43215
Manchester, CT
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Nashville, Tennessee
332
mi
from 43215
Nashville, TN
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New Brunswick, New Jersey
453
mi
from 43215
New Brunswick, NJ
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New London, Connecticut
580
mi
from 43215
New London, CT
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New York, New York
477
mi
from 43215
New York, NY
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New York, New York
477
mi
from 43215
New York, NY
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Ormond Beach, Florida
746
mi
from 43215
Ormond Beach, FL
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Philadephia, Pennsylvania
317
mi
from 43215
Philadephia, PA
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Port Charlotte, Florida
899
mi
from 43215
Port Charlotte, FL
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Raleigh, North Carolina
374
mi
from 43215
Raleigh, NC
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Salt Lake City, Utah
1513
mi
from 43215
Salt Lake City, UT
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San Antonio, Texas
1138
mi
from 43215
San Antonio, TX
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San Bernadino, California
1969
mi
from 43215
San Bernadino, CA
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St. Petersburg, Florida
842
mi
from 43215
St. Petersburg, FL
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Sun City, Arizona
1669
mi
from 43215
Sun City, AZ
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119
mi
from 43215
Toledo, OH
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Washington, District of Columbia
327
mi
from 43215
Washington,
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