Effect of Nasaleze on Nasal Challenge With Allergen
| Status: | Completed |
|---|---|
| Conditions: | Allergy |
| Therapuetic Areas: | Otolaryngology |
| Healthy: | No |
| Age Range: | 18 - 45 |
| Updated: | 4/2/2016 |
| Start Date: | November 2012 |
| End Date: | December 2013 |
| Contact: | James Lane, BS |
| Email: | jlane@surgery.bsd.uchicago.edu |
| Phone: | 773-702-5889 |
Effect of Nasaleze on the Early Reaction to Nasal Challenge With Allergen
The objectives of this protocol are:
1. to confirm the inhibitory effect of Nasaleze on the immediate response to nasal
challenge with antigen, and
2. to show that inhibition of the immediate response to nasal challenge with antigen by
Nasaleze inhibits subsequent inflammatory events.
1. to confirm the inhibitory effect of Nasaleze on the immediate response to nasal
challenge with antigen, and
2. to show that inhibition of the immediate response to nasal challenge with antigen by
Nasaleze inhibits subsequent inflammatory events.
Inclusion Criteria
1. Males and females between 18 and 45 years of age.
2. History of grass and/or ragweed allergic rhinitis.
3. Positive skin test to grass and/or ragweed antigen.
4. Positive response to screening nasal challenge.
Exclusion Criteria:
1. Physical signs or symptoms suggestive of renal, hepatic or cardiovascular disease.
2. Pregnant or lactating women.
3. Upper respiratory infection within 14 days of study start.
4. FEV1<80% of predicted at screening for subjects with history of mild asthma.
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