The Role of Antidepressants or Antipsychotics in Preventing Psychosis



Status:Completed
Conditions:Psychiatric
Therapuetic Areas:Psychiatry / Psychology
Healthy:No
Age Range:12 - 25
Updated:5/5/2014
Start Date:October 2012
End Date:December 2013
Contact:Michael L Birnbaum, MDCM
Email:mbirnbau@chpnet.org
Phone:212-523-2932

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Trial Summary
Trial Overview
Inclusion Criteria
This is a randomized, controlled pilot study comparing the antidepressant fluoxetine with
the second generation antipsychotic aripiprazole in approximately 10 subjects aged 12-25 at
risk for developing psychosis.

Our primary hypotheses are that compared to aripiprazole, fluoxetine will be better
tolerated and will lead to greater improvement in symptoms at the end of 6 months of
treatment.


Inclusion Criteria:

- 12-25 years of age (inclusive)

- Able to understand and speak English

- Have at least one sub-threshold positive psychotic symptom that is moderate,
moderately severe, or severe

Exclusion Criteria:

- Lifetime diagnosis of an Axis I psychotic disorder: schizophreniform disorder;
schizophrenia; schizoaffective disorder; bipolar disorder; or major depression with
psychotic features

- Current psychosis

- Current diagnosis of Major Depressive Disorder, single episode or recurrent, severe
without psychotic features

- Lifetime diagnosis of substance abuse or dependence (excluding nicotine)

- Current stimulant treatment

- Any significant medical condition that contra-indicates treatment with either
aripiprazole or fluoxetine, including history of neurological, neuroendocrine or
other medical condition known to affect the brain

- Estimated intelligence quotient < 70
We found this trial at
1
site
St. Luke's Hospital
New York, New York 10025
?
mi
from
New York, NY
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