Vancomycin Versus Ceftaroline in Patients With Infections Caused by MRSA That Are Susceptible to Ceftaroline

Inclusion Criteria:

1. A positive MRSA culture, resulting from a blood or properly obtained infection site
sample, with a vancomycin MIC 1.5 - 4.0 mcg/mL and ceftaroline MIC ≤1 mcg/mL.

2. The patient was treated adequately with ceftaroline or vancomycin.

3. A medical history, clinical signs and symptoms, and radiological findings consistent
with infection such as pneumonia, skin and wound, intra-abdominal infection and
bacteremia associated with one of those infection sites.

Patients must have had a body temperature >38C [100.4F] or <36.1C [97F] or
leukocytosis (blood leukocyte count >10,000 cells/mm3) or >10% bands, at baseline. In
the case of pneumonia, chest radiographic examination that show a new or progressive
infiltrate, consolidation, cavitation, or pleural effusion. Rales or dullness to
percussion on physical examination of the chest, new onset of purulent sputum, or
change in quantity or character of sputum. Wound redness, swelling, and/or purulence
in the case of ABSSSI

4. There should be sufficient numbers of follow up cultures of the infection site and/or
blood to determine whether the infecting pathogen was eradicated, and preferably the
day on which the eradication occurred.

Additional inclusion criteria for patients with pneumonia:

1. Suspected or confirmed acute bacterial pneumonia due to MRSA in one of the following
subgroups:

Community-acquired bacterial pneumonia (CABP) i.e. those cases acquired outside the
hospital and being admitted to the hospital for treatment of their pneumonia;

or

Hospital-acquired bacterial pneumonia (HABP), i.e., pneumonia that occurs 72 hours or
more after admission, which was not incubating at the time of admission;

or

Ventilator-associated bacterial pneumonia (VABP), i.e., pneumonia that arises more
than 48 hours after endotracheal intubation and ventilation;

or

Health Care-associated bacterial pneumonia (HCABP), which includes patients admitted
from a long term care facility.

2. Pulmonary infiltration consistent with the diagnosis of pneumonia (new or progressive
infiltrates, consolidation, with or without the presence of pleural effusion)
documented by chest X-ray or CT within 48 hours prior to enrollment.

3. Suitable respiratory specimen (sputum/endotracheal specimen or specimen from an
invasive procedure) for culture and Gram stain, with Gram-positive pathogens as the
predominant organism. Average of at least 10 Gram-positive organisms per
oil-immersion field in 10 fields (actual or calculated, 100x objective).

Additional inclusion criteria for patients with other infection sites:

1. In all cases of bacteremia linked to a site/source, the isolate species and
susceptibility should match between blood and primary site. Typical non-pneumonia
sites of infection will include complicated intra-abdominal (cIAI) and ABSSSI.

2. In contrast, bacteremic patients with IV catheter as the only source will require
that the catheter was removed/replaced, and yet the patient remains culture positive
for at least 24 hr after replacement of the catheter.

Exclusion Criteria

1. Age <18 years

2. Pregnant or lactating women

3. Life expectancy <3 months from underlying disease

4. Infection with Mycobacterium tuberculosis

5. Organism is not available or is not tested locally for MIC to ceftaroline or
vancomycin

6. Bacteremia determined to be catheter-related with no definitive evidence of a
secondary source

7. Patient is on a prior antibiotic and shows clinical improvement or negative cultures
before treatment of ceftaroline (or vancomycin for control patients).