Protocol-driven Hemodynamic Support for Patients With Septic Shock
| Status: | Completed |
|---|---|
| Conditions: | Hospital |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 4/2/2016 |
| Start Date: | September 2006 |
| End Date: | January 2011 |
| Contact: | Jonathan E Sevransky, MD |
| Email: | jsevran1@jhmi.edu |
| Phone: | 410-550-0546 |
This research is being done to see if a protocol (a set of orders that determine how much
and how quickly a drug/fluid is given) for fluid and drugs used to increase blood pressure
(vasopressors) will work better then general clinical practices to improve outcomes in
patients with septic shock.
and how quickly a drug/fluid is given) for fluid and drugs used to increase blood pressure
(vasopressors) will work better then general clinical practices to improve outcomes in
patients with septic shock.
Septic shock is low blood pressure caused by an infection. Sepsis is the most common cause
of death in non-cardiac intensive care units, and septic shock is the most severe form of
sepsis. Treatment for septic shock includes giving antibiotics, intravenous fluids, and
medications to raise the blood pressure (vasopressors).
We would like to see if a protocol-driven management strategy for septic shock can shorten
time on vasopressors and limit the number of side effects. We have constructed a protocol
that will allow the nurse at the bedside, in conjunction with the physician's orders, to
adjust the amount of fluids and medications that raise the blood pressure (vasopressors).
of death in non-cardiac intensive care units, and septic shock is the most severe form of
sepsis. Treatment for septic shock includes giving antibiotics, intravenous fluids, and
medications to raise the blood pressure (vasopressors).
We would like to see if a protocol-driven management strategy for septic shock can shorten
time on vasopressors and limit the number of side effects. We have constructed a protocol
that will allow the nurse at the bedside, in conjunction with the physician's orders, to
adjust the amount of fluids and medications that raise the blood pressure (vasopressors).
Inclusion Criteria:
- ACCP/SCCM sepsis criteria
- Need for institution of vasopressors after adequate volume resuscitation
Exclusion Criteria:
- Age< 18
- On vasopressors for > 24 hours prior to ICU admission
- Other cause for shock ( cardiac tamponade, massive pulmonary embolus, cardiogenic
shock)
- Physicians and family not committed to aggressive medical therapy ( a patient will
not be excluded if he/she would receive all care except for attempts at resuscitation
from cardiac arrest)
We found this trial at
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Johns Hopkins Bayview Medical Center There is no better story in American medicine in the...
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