Evaluation of Biomarkers of Traumatic Brain Injury

Inclusion Criteria:

- subject is at least 18 years of age at screening

- suspected traumatically induced head injury as a result of insult to the head from
external force

- GCS 9-15 at time of informed consent

- workup includes head CT scan as part of clinical emergency care within 3 hours of
presenting and within 12 hours of injury

- blood sample collected within 3 hours of presenting and within 12 hours of injury

- subject or legal representative is willing to undergo informed consent

Exclusion Criteria:

- participating in an interventional, therapeutic clinical study that may affect the
results of this study (an observational study acceptable)

- time of injury cannot be determined

- primary diagnosis of ischemic or hemorrhagic stroke

- venipuncture not feasible

- a condition precluding entry into the CT scanner

- subject has a neurodegenerative disease or other neurological disorder including
dementia, Parkinson's disease, multiple sclerosis, seizure disorder, brain tumors, and
history of neurosurgery, stroke or TIA within the last 30 days

- administration of blood transfusion after head injury and prior to study blood draw

- subject is otherwise determined by the Investigator to be unsuitable for participation