Study to Evaluate Safety & Tolerability of BMS-906024 in Combination With Chemotherapy & to Define DLTs & MTD of BMS-906024 in Combination With One of the Following Chemotherapy Regimens; Weekly Paclitaxel, 5FU+Irinotecan or Carboplatin+Paclitaxel in Subjects With Advanced / Metastatic Solid Tumors



Status:Completed
Conditions:Cancer
Therapuetic Areas:Oncology
Healthy:No
Age Range:18 - Any
Updated:12/21/2017
Start Date:October 12, 2012
End Date:May 3, 2017

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A Phase Ib Ascending Multi-arm, Dose Escalation Study of BMS-906024 Combined With Several Chemotherapy Regimens in Subjects With Advanced or Metastatic Tumors

The purpose of this study is to identify a safe and tolerable dose of BMS-906024 in
combination with each of the following three chemotherapy regimens: Paclitaxel, 5FU plus
Irinotecan (FOLFIRI), or Carboplatin plus Paclitaxel in subjects with advanced or metastatic
solid tumors

DLTs = dose-limiting toxicities

MTD = Maximum tolerated dose

For more information regarding BMS clinical trial participation, please visit
www.BMSStudyConnect.com.

Inclusion Criteria:

- Subjects with advanced or metastatic solid tumors for whom a chemotherapy regimen is
considered appropriate

- Subjects with non-small cell lung cancer and triple-negative breast cancer are
preferred

- Biopsy accessible tumor (may use archived tumor samples under certain circumstances)

- Life expectancy of at least 3 months

- Eastern Cooperative Oncology Group (ECOG) Performance Status of 0-1

- Measurable disease

Exclusion Criteria:

- Uncontrolled brain metastases

- Infection

- Gastrointestinal (GI) disease with increased risk of diarrhea (e.g. inflammatory bowel
disease)

- Uncontrolled or significant cardiovascular disease

- Subjects taking medications known to increase risk of Torsades de Pointes
We found this trial at
2
sites
Los Angeles, California 90095
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Brussels,
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