Pharmacokinetics (PK) of Antistaphylococcal Antibiotics in Infants (NICHD-2012-02-Staph Trio)
Status: | Completed |
---|---|
Conditions: | Hospital |
Therapuetic Areas: | Other |
Healthy: | No |
Age Range: | Any |
Updated: | 12/26/2018 |
Start Date: | January 2013 |
End Date: | May 2015 |
Pharmacokinetics of Antistaphylococcal Antibiotics in Infants
Multiple center, open-label, PK study
Pharmacokinetics of rifampin, ticarcillin-clavulanate, and clindamycin antibiotics in
hospitalized infants with suspected systemic infection or receiving one of the study drugs
per local standard of care. Number of participants are 16-32 evaluable per each study drug of
rifampin, ticarcillin-clavulanate, and clindamycin antibiotics.
hospitalized infants with suspected systemic infection or receiving one of the study drugs
per local standard of care. Number of participants are 16-32 evaluable per each study drug of
rifampin, ticarcillin-clavulanate, and clindamycin antibiotics.
Inclusion Criteria:
- Sufficient intravascular access
- Suspected systemic infection or receiving 1 of the study drugs per standard of care
- informed consent from legal guardian
Exclusion Criteria:
- history of allergic reaction to study drugs
- urine output <0.5 mL/hr/kg over the prior 24 hours
- serum creatinine >1.7 mg/dl
- Any condition in investigator judgment precludes participation because it could affect
participant safety
We found this trial at
10
sites
Indiana University INDIANA UNIVERSITY is a major multi-campus public research institution, grounded in the liberal...
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Emory University Emory University, recognized internationally for its outstanding liberal artscolleges, graduate and professional schools,...
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Tufts Medical Center Tufts Medical Center is an internationally-respected academic medical center – a teaching...
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Duke University Younger than most other prestigious U.S. research universities, Duke University consistently ranks among...
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University of Louisville The University of Louisville is a state supported research university located in...
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