Pharmacokinetics (PK) of Antistaphylococcal Antibiotics in Infants (NICHD-2012-02-Staph Trio)



Status:Completed
Conditions:Hospital
Therapuetic Areas:Other
Healthy:No
Age Range:Any
Updated:12/26/2018
Start Date:January 2013
End Date:May 2015

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Pharmacokinetics of Antistaphylococcal Antibiotics in Infants

Multiple center, open-label, PK study

Pharmacokinetics of rifampin, ticarcillin-clavulanate, and clindamycin antibiotics in
hospitalized infants with suspected systemic infection or receiving one of the study drugs
per local standard of care. Number of participants are 16-32 evaluable per each study drug of
rifampin, ticarcillin-clavulanate, and clindamycin antibiotics.

Inclusion Criteria:

- Sufficient intravascular access

- Suspected systemic infection or receiving 1 of the study drugs per standard of care

- informed consent from legal guardian

Exclusion Criteria:

- history of allergic reaction to study drugs

- urine output <0.5 mL/hr/kg over the prior 24 hours

- serum creatinine >1.7 mg/dl

- Any condition in investigator judgment precludes participation because it could affect
participant safety
We found this trial at
10
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425 University Blvd.
Indianapolis, Indiana 46202
(317) 274-4591
Indiana University INDIANA UNIVERSITY is a major multi-campus public research institution, grounded in the liberal...
1866
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Indianapolis, IN
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201 Dowman Dr
Atlanta, Georgia 30303
(404) 727-6123
Emory University Emory University, recognized internationally for its outstanding liberal artscolleges, graduate and professional schools,...
2178
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Atlanta, GA
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800 Washington St
Boston, Massachusetts 02111
(617) 636-5000
Tufts Medical Center Tufts Medical Center is an internationally-respected academic medical center – a teaching...
2485
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Boston, MA
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Durham, North Carolina 27710
(919) 684-8111
Duke University Younger than most other prestigious U.S. research universities, Duke University consistently ranks among...
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Durham, NC
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Brooklyn, New York 11203
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Brooklyn, NY
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Gainesville, Florida 32610
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Gainesville, FL
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1937
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Galveston, TX
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Jacksonville, Florida 32209
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Jacksonville, FL
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500 S Preston St
Louisville, Kentucky
(502) 852-5555
University of Louisville The University of Louisville is a state supported research university located in...
1938
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Louisville, KY
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Wichita, Kansas 67214
1436
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Wichita, KS
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