Pharmacokinetics (PK) of Antistaphylococcal Antibiotics in Infants (NICHD-2012-02-Staph Trio)

Pharmacokinetics of rifampin, ticarcillin-clavulanate, and clindamycin antibiotics in
hospitalized infants with suspected systemic infection or receiving one of the study drugs
per local standard of care. Number of participants are 16-32 evaluable per each study drug of
rifampin, ticarcillin-clavulanate, and clindamycin antibiotics.

Inclusion Criteria:

- Sufficient intravascular access

- Suspected systemic infection or receiving 1 of the study drugs per standard of care

- informed consent from legal guardian

Exclusion Criteria:

- history of allergic reaction to study drugs

- urine output <0.5 mL/hr/kg over the prior 24 hours

- serum creatinine >1.7 mg/dl

- Any condition in investigator judgment precludes participation because it could affect
participant safety