Methadone Oxytocin Option
| Status: | Completed |
|---|---|
| Conditions: | Psychiatric, Gastrointestinal |
| Therapuetic Areas: | Gastroenterology, Psychiatry / Psychology |
| Healthy: | No |
| Age Range: | 18 - Any |
| Updated: | 10/20/2018 |
| Start Date: | May 2012 |
| End Date: | October 2014 |
The Effects of Intranasal Oxytocin on Social Cognition and Social Approach Behaviors in Opioid-dependent Patients
The purpose of the study is to examine the effects of intranasal oxytocin administration on
social cognition in patients receiving methadone maintenance treatment (MMT), examine the
effects of intranasal oxytocin administration on opioid craving and on the subjective effects
of methadone, and examine the effects of intranasal oxytocin administration on implicit
preferences for drug-related and social stimuli in patients receiving MMT.
Hypothesis 1: Patients will perform better on measures of social cognition (including affect
recognition and recognition of sarcasm) after administration of oxytocin compared with
placebo.
Hypothesis 2: Patients will demonstrate lower craving for opioids and greater subjective
effects of methadone after administration of oxytocin compared with placebo.
Hypothesis 3: Patients will demonstrate increased implicit preferences for social stimuli and
decreased implicit preferences for drug related stimuli after administration of oxytocin
compared with placebo.
social cognition in patients receiving methadone maintenance treatment (MMT), examine the
effects of intranasal oxytocin administration on opioid craving and on the subjective effects
of methadone, and examine the effects of intranasal oxytocin administration on implicit
preferences for drug-related and social stimuli in patients receiving MMT.
Hypothesis 1: Patients will perform better on measures of social cognition (including affect
recognition and recognition of sarcasm) after administration of oxytocin compared with
placebo.
Hypothesis 2: Patients will demonstrate lower craving for opioids and greater subjective
effects of methadone after administration of oxytocin compared with placebo.
Hypothesis 3: Patients will demonstrate increased implicit preferences for social stimuli and
decreased implicit preferences for drug related stimuli after administration of oxytocin
compared with placebo.
Inclusion Criteria for patients:
- Primary diagnosis of opioid dependence according to DSM-IV TR
- Opioid of choice be either heroin or oral opioid analgesics
- Currently be on stable dose of methadone with no dose change in the last 14 days
Inclusion Criteria for healthy volunteers
-No diagnosis of mental disorder according to DSM-IV TR
Exclusion Criteria for patients and healthy volunteers:
- Epilepsy
- Current illicit drug use (within the past one month)
- Current sever depression with suicidal thoughts and/or actions
- Addiction to alcohol or drugs other than opiates, caffeine, or nicotine
- Psychotic illness
- Bipolar disorder
- Brain trauma
- Severe Neuropsychological disorder
- Kidney Disease (i.e., kidney stones, recurrent bladder infections, or known kidney
failure)
- Sensitivity to preservatives (in particular E216, E218, and chlorobutanol hemihydrate)
- Nasal obstruction, discharge, or bleeding
- Cardiovascular problems (e.g., heart disease, history of heart attacks), high blood
pressure (hypertension)
- Habitually drink large volumes of water
We found this trial at
1
site
Click here to add this to my saved trials
