Dietary Interventions in Prediabetes
| Status: | Completed |
|---|---|
| Conditions: | Endocrine, Diabetes |
| Therapuetic Areas: | Endocrinology |
| Healthy: | No |
| Age Range: | 30 - 80 |
| Updated: | 4/21/2016 |
| Start Date: | October 2012 |
| End Date: | February 2014 |
The Effects of Dietary Supplementation on Hepatic Insulin Action and Glucose Tolerance in Pre-diabetes
Assessment of glucose metabolism and liver fat after 12 week dietary intervention in pre
diabetes subjects. Subjects will be randomized to either high fat (olive oil
supplemented),high carb/high fiber (beans supplemented) and high carb/low fiber diets.
Glucose metabolism will be assessed by labeled oral glucose tolerance test and liver fat by
magnetic resonance spectroscopy pre randomization and at 8 and 12 week after starting
dietary intervention.
diabetes subjects. Subjects will be randomized to either high fat (olive oil
supplemented),high carb/high fiber (beans supplemented) and high carb/low fiber diets.
Glucose metabolism will be assessed by labeled oral glucose tolerance test and liver fat by
magnetic resonance spectroscopy pre randomization and at 8 and 12 week after starting
dietary intervention.
Inclusion Criteria:
- Impaired fasting glucose(100-125 mg/dl)
- HbA1c 5.7-6.4 %
- BMI 26-40 kg/sq.m
Exclusion Criteria:
- MRS contraindication
- Pregnant women
- Liver disease
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