Safety, Tolerability and Efficacy of ACZ885 on Leg Artery Structure in Patients With Peripheral Artery Disease

Key Inclusion Criteria:

- Must have a signed informed consent form.

- Must be between the ages of 18 and 85

- Must experience leg pain associated with walking and have an ankle brachial index
between 0.40 and 0.9

- Must be on stable aspirin and statin doses for at least 6 weeks

- Blood pressure within ranges specified in the protocol

- Able to communicate well with the Investigator and understand and comply with the
study procedures

Key Exclusion Criteria:

- Recent use of any other experimental drugs

- Pregnant or nursing women

- Women of child bearing potential unless willing to use contraception as detailed in
the protocol

- Cannot walk 15 meters (50 feet)

- People on restricted medications as listed in the protocol

- Any open or non-healing wounds with 3 months of study start or infection within 2
weeks or study start

- Significant heart disease

- Uncontrolled diabetes

- Significant kidney or liver disease

- Live vaccinations within 3 months of study start

- History of untreated tuberculosis or active tuberculosis (TB)

- Patients with metal in their body (excluded due to MRI scan) as detailed in the
protocol.