A Study of the Effect of Arterial Carbon Dioxide Tension on the Recovery of Spontaneous Respiration
| Status: | Completed |
|---|---|
| Conditions: | Hospital |
| Therapuetic Areas: | Other |
| Healthy: | No |
| Age Range: | 18 - 80 |
| Updated: | 4/25/2018 |
| Start Date: | September 2012 |
| End Date: | February 2018 |
A Study of the Effect of Arterial Carbon Dioxide Tension on the Recovery of Spontaneous Respiration With Respiratory Inductance Plethysmography (RIP) During High Frequency Jet Ventilation (HFJV) Under General Anesthesia
The investigators data reveal an important new observation regarding the recovery of
breathing during emergence from general anesthesia: respiration resumes as a prolonged
abdominal expiration event.
The present study aims to further clarify the physiology of recovery of breathing with the
addition of a cutaneous monitor for arterial carbon dioxide measurement and a comparison of
two different recovery paradigms.
breathing during emergence from general anesthesia: respiration resumes as a prolonged
abdominal expiration event.
The present study aims to further clarify the physiology of recovery of breathing with the
addition of a cutaneous monitor for arterial carbon dioxide measurement and a comparison of
two different recovery paradigms.
The present study will use non-invasive respiratory inductance plethysmography(RIP) and
transcutaneous carbon dioxide measurement to compare recovery of respiration under constant
Transcutaneous carbon dioxide measurement( ptcCO2) with continuous high frequency jet
ventilation HFJV (study method) with recovery of respiration during rising and apnea (current
standard).
The investigators hypothesize that the prolonged abdominal expiration that we observed during
recovery of breathing in prior studies will be unaffected by arterial carbon dioxide (CO2)
levels.
transcutaneous carbon dioxide measurement to compare recovery of respiration under constant
Transcutaneous carbon dioxide measurement( ptcCO2) with continuous high frequency jet
ventilation HFJV (study method) with recovery of respiration during rising and apnea (current
standard).
The investigators hypothesize that the prolonged abdominal expiration that we observed during
recovery of breathing in prior studies will be unaffected by arterial carbon dioxide (CO2)
levels.
Inclusion Criteria:
1. Male or Female patients ages > 18 to < 80
2. Scheduled for procedures under general anesthesia with jet ventilation
3. Sign informed consent
4. Candidate for total intravenous anesthesia with propofol and remifentanil (which is
standard protocol in this type of population)
Exclusion Criteria:
1. Absence of informed consent
2. No planned use intra-operative use of jet ventilation
3. Known difficulties with jet ventilation during prior surgical procedures
4. Emergency surgery
5. Baseline (oxygen saturation)SpO2 <92% on room air
6. BMI > 50
7. Pregnant or lactating females
8. Skin damage, rash or significant lesions in the areas covered by the RIP bands or
transcutaneous CO2 sensor.
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