Mechanisms of Pharyngeal Collapse in Sleep Apnea, Study D
| Status: | Completed |
|---|---|
| Conditions: | Insomnia Sleep Studies, Pulmonary |
| Therapuetic Areas: | Psychiatry / Psychology, Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 21 - 65 |
| Updated: | 4/2/2016 |
| Start Date: | December 2012 |
| End Date: | December 2014 |
| Contact: | Pedro R Genta, MD |
| Email: | pgenta@partners.org |
| Phone: | (617) 732-6541 |
In obstructive sleep apnea (OSA), the upper airway recurrently closes during sleep. The
mechanisms that lead to airway closure are not completely understood. Some studies have
shown that there is progressive narrowing of the pharyngeal airway across breaths during
expiration (Progressive Expiratory Narrowing, PEN) preceding an obstructive apnea. The
investigators will assess the viscoelastic properties of the pharyngeal airway and its role
in PEN.
mechanisms that lead to airway closure are not completely understood. Some studies have
shown that there is progressive narrowing of the pharyngeal airway across breaths during
expiration (Progressive Expiratory Narrowing, PEN) preceding an obstructive apnea. The
investigators will assess the viscoelastic properties of the pharyngeal airway and its role
in PEN.
In obstructive sleep apnea, the upper airway recurrently closes during sleep. The mechanisms
that lead to airway closure are not completely understood. Some studies have shown that
there is progressive narrowing of the pharyngeal airway across breaths during expiration
(Progressive Expiratory Narrowing, PEN) preceding an obstructive apnea.
The investigators will test how the viscoelastic properties of the airway influence PEN. To
this end, the investigators will visualize the pharynx of sleep apnea patients using a thin
endoscope and will induce central apneas during sleep. Pharyngeal cross-sectional area will
be recorded during incremental changes in pharyngeal pressure during central apneas.
that lead to airway closure are not completely understood. Some studies have shown that
there is progressive narrowing of the pharyngeal airway across breaths during expiration
(Progressive Expiratory Narrowing, PEN) preceding an obstructive apnea.
The investigators will test how the viscoelastic properties of the airway influence PEN. To
this end, the investigators will visualize the pharynx of sleep apnea patients using a thin
endoscope and will induce central apneas during sleep. Pharyngeal cross-sectional area will
be recorded during incremental changes in pharyngeal pressure during central apneas.
Inclusion Criteria:
- Normal subjects or patients with OSA
Exclusion Criteria:
- Any unstable cardiac condition (other than well controlled hypertension) or pulmonary
problems.
- Any medication known to influence breathing, sleep/arousal or muscle physiology
- Concurrent sleep disorders (insomnia, narcolepsy, central sleep apnea or parasomnia)
- Claustrophobia
- Inability to sleep supine
- Allergy to lidocaine or oxymetazoline hydrochloride
- For women: Pregnancy
We found this trial at
1
site
Brigham and Women's Hosp Boston’s Brigham and Women’s Hospital (BWH) is an international leader in...
Click here to add this to my saved trials
