The Role of HIF-2a in the Pathogenesis of Reflux Esophagitis



Status:Active, not recruiting
Conditions:Gastroesophageal Reflux Disease , Gastrointestinal
Therapuetic Areas:Gastroenterology
Healthy:No
Age Range:18 - Any
Updated:8/17/2018
Start Date:February 2013
End Date:July 2019

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Trial Summary
Trial Overview
Inclusion Criteria
The purpose of this study is to determine the role of hypoxia inducible factor (HIF)-2a on
the production of inflammatory cytokines that lead to reflux esophagitis.

Reflux esophagitis is thought to be caused by gastric acid that refluxes into the esophagus,
causing injury. Newer data suggest that reflux of gastric juice into the esophagus stimulates
HIF-2a, which increases production of inflammatory cytokines. These cytokines are thought to
lead to reflux esophagitis. The investigators plan to study the relationship of HIF-2a to
inflammatory cytokines in patients with known gastroesophageal reflux disease and reflux
esophagitis.

Inclusion Criteria:

- U.S Veteran

- History of Los Angeles Grade C erosive esophagitis

Exclusion Criteria:

- Inability to provide informed consent

- Esophageal varices

- Warfarin use

- Coagulopathy that precludes safe biopsy of the esophagus

- Comorbidity that precludes safe participation in the study

- Allergy to fluorescein sodium

- Pregnancy
We found this trial at
2
sites
Dallas VA Medical Center
4500 S. Lancaster Rd.
Dallas, Texas 75216
800-849-3597
Dallas VA Medical Center VA North Texas Health Care System (VANTHCS) is a progressive health...
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from
Dallas, TX
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Dallas VA Medical Center
4500 S. Lancaster Rd.
Dallas, Texas 75216
800-849-3597
Dallas VA Medical Center VA North Texas Health Care System (VANTHCS) is a progressive health...
?
mi
from
Dallas, TX
Click here to add this to my saved trials