Evaluation of Purified Poloxamer 188 in Vaso-Occlusive Crisis of Sickle Cell Disease (EPIC)



Status:Recruiting
Conditions:Anemia
Therapuetic Areas:Hematology
Healthy:No
Age Range:4 - 65
Updated:4/21/2016
Start Date:May 2013
Contact:Mast Therapeutics CT.gov Call Center
Phone:1-888-965-1238

Use our guide to learn which trials are right for you!

Trial Summary
Trial Overview
Inclusion Criteria

Evaluation of Purified Poloxamer 188 in Vaso-Occlusive Crisis of Sickle Cell Disease (EPIC): A Phase 3 Randomized, Double-Blind, Placebo-Controlled, Multicenter Clinical Trial of MST-188 (Purified Poloxamer 188) Injection in Subjects With Sickle Cell Disease Experiencing Vaso Occlusive Crisis

The purpose of this study is to evaluate whether MST-188 can reduce the duration of
vaso-occlusive crisis (VOC) in subjects with sickle cell disease. The study will also
evaluate whether MST-188 can reduce the frequency of rehospitalization of subjects due to a
recurrence of VOC. Additionally, this study will compare the development of acute chest
syndrome during VOC in subjects who receive MST-188 to those who do not receive MST-188.


Inclusion Criteria:

- Age 4 through 65 years

- Subject has a confirmed diagnosis of HbSS, HbSC, HbSβ+thal, or HbSβ0thal

- Subject is experiencing acute pain typical of vaso-occlusive crisis requiring
treatment with parenteral analgesia

- Subject requires hospitalization

Exclusion Criteria:

- Subject has acute chest syndrome

- Subject's laboratory results indicate inadequate organ function

- Subject is pregnant or nursing an infant

- Subject had a painful crisis requiring hospitalization within the preceding 14 days
or has experienced > 5 hospitalizations for VOC in the prior 6 months

- Subject has been transfused within the past 14 days

- Subject is hospitalized for a condition other than VOC

- Subject has complications related to SCD
We found this trial at
51
sites
University of North Carolina at Chapel Hill
Chapel Hill, North Carolina 27599
(919) 962-2211
University of North Carolina at Chapel Hill Carolina’s vibrant people and programs attest to the...
?
mi
from
Chapel Hill, NC
Click here to add this to my saved trials
T.C. Thompson Children's Hospital
910 Blackford street
Chattanooga, Tennessee 37403
Phone: 423-778-7024
?
mi
from
Chattanooga, TN
Click here to add this to my saved trials
Cincinnati Children's Hospital Medical Center
3333 Burnet Avenue # Mlc3008
Cincinnati, Ohio 45229
 1-513-636-4200 
Cincinnati Children's Hospital Medical Center Patients and families from across the region and around the...
?
mi
from
Cincinnati, OH
Click here to add this to my saved trials
Rainbow Babies and Children's Hospital
11100 Euclid Avenue
Cleveland, Ohio 44106
(216) 844-1000
Rainbow Babies and Children's Hospital UH Rainbow Babies & Children’s Hospital is a 244-bed, full-service...
?
mi
from
Cleveland, OH
Click here to add this to my saved trials
Children's Hospital of Southwest Florida
9981 South Healthpark Drive
Fort Myers, Florida 33908
?
mi
from
Fort Myers, FL
Click here to add this to my saved trials
Joe DiMaggio Children's Hospital
1000 Joe DiMaggio Drive
Hollywood, Florida 33021
?
mi
from
Hollywood, FL
Click here to add this to my saved trials
University of Mississippi Medical Center
2500 N State St
Jackson, Mississippi 39216
(601) 984-1000
Phone: 601-815-9185
University of Mississippi Medical Center The University of Mississippi Medical Center, located in Jackson, is...
?
mi
from
Jackson, MS
Click here to add this to my saved trials
University of Miami
Miami, Florida 33124
(305) 284-2211
Phone: 305-243-9431
University of Miami A private research university with more than 15,000 students from around the...
?
mi
from
Miami, FL
Click here to add this to my saved trials
Miami Children's Hospital
3100 SW 62nd Ave
Miami, Florida 33155
(305) 666-6511
Phone: 786-662-4146
Miami Children's Hospital Welcome to Miami Children
?
mi
from
Miami, FL
Click here to add this to my saved trials
Children's Hospital of The King's Daughters
601 Children's Lane
Norfolk, Virginia 23507
(757) 668-7000
Children's Hospital of The King's Daughters Children
?
mi
from
Norfolk, VA
Click here to add this to my saved trials
Children's Hospital of Philadelphia
South 34th Street
Philadelphia, Pennsylvania 19104
 215-590-1000
Children's Hospital of Philadelphia Since its start in 1855 as the nation's first hospital devoted...
?
mi
from
Philadelphia, PA
Click here to add this to my saved trials
Tampa General Hospital
1 Tampa General Cir
Tampa, Florida 33606
(813) 844-7000
Phone: 813-844-7829
Tampa General Hospital In a diverse city known for its rich culture and beautiful beaches,...
?
mi
from
Tampa, FL
Click here to add this to my saved trials
Reearch Center
Antwerp,
?
mi
from
Antwerp,
Click here to add this to my saved trials
Grady Memorial Hospital
80 Jesse Hill Jr Dr SE
Atlanta, Georgia 30303
(404) 616-1000
Grady Memorial Hospital Grady is an internationally recognized teaching hospital staffed exclusively by doctors from...
?
mi
from
Atlanta, GA
Click here to add this to my saved trials
Augusta University
1120 15th Street
Augusta, Georgia 30912
(706) 721-0211
Phone: 706-721-0174
Georgia Regents University Georgia Regents University, home of the Medical College of Georgia, is one...
?
mi
from
Augusta, GA
Click here to add this to my saved trials
Johns Hopkins
Baltimore, Maryland 21218
(410) 516-8000
Johns Hopkins The Johns Hopkins University opened in 1876, with the inauguration of its first...
?
mi
from
Baltimore, MD
Click here to add this to my saved trials
The Herman and Walter Samuelson Children's Hospital at Sinai
Baltimore, Maryland 21215
?
mi
from
Baltimore, MD
Click here to add this to my saved trials
Our Lady of the Lake Children's Hospital
Baton Rouge, Louisiana 70808
?
mi
from
Baton Rouge, LA
Click here to add this to my saved trials
Bronx/Lebanon Hospital
Bronx, New York 10457
?
mi
from
Bronx, NY
Click here to add this to my saved trials
NY Methodist
Brooklyn, New York 11215
Phone: 718-780-5282
?
mi
from
Brooklyn, NY
Click here to add this to my saved trials
Medical University of South Carolina
171 Ashley Avenue
Charleston, South Carolina 29425
843-792-1414
Medical University of South Carolina The Medical University of South Carolina (MUSC) has grown from...
?
mi
from
Charleston, SC
Click here to add this to my saved trials
University of Virginia Medical Center
Charlottsville, Virginia 22908
?
mi
from
Charlottsville, VA
Click here to add this to my saved trials
Ann & Robert H. Lurie Children's Hospital of Chicago
225 E Chicago Ave
Chicago, Illinois 60611
(312) 227-4000
Phone: 312-227-4825
Ann & Robert H. Lurie Children's Hospital of Chicago Ann & Robert H. Lurie Children
?
mi
from
Chicago, IL
Click here to add this to my saved trials
Children's Hospital of the University of Illinois
Chicago, Illinois 60612
?
mi
from
Chicago, IL
Click here to add this to my saved trials
Children's Hospital of Michigan, Wayne State University
Detroit, Michigan 48201
?
mi
from
Detroit, MI
Click here to add this to my saved trials
Duke Univ Med Ctr
2301 Erwin Rd
Durham, North Carolina 27710
919-684-8111
Duke Univ Med Ctr As a world-class academic and health care system, Duke Medicine strives...
?
mi
from
Durham, NC
Click here to add this to my saved trials
Hurley Research Center
Flint, Michigan 48503
?
mi
from
Flint, MI
Click here to add this to my saved trials
Cook's Children Hospital
Fort Worth, Texas 76104
?
mi
from
Fort Worth, TX
Click here to add this to my saved trials
Fort Wayne Lutheran Hospital
7950 West Jefferson Boulevard
Ft. Wayne, Indiana 46804
Phone: 260-435-2501
?
mi
from
Ft. Wayne, IN
Click here to add this to my saved trials
East Carolina University
1001 E 5th St
Greenville, North Carolina 27858
(252) 328-6131
East Carolina University Whether it's meeting the demand for more teachers and healthcare professionals or...
?
mi
from
Greenville, NC
Click here to add this to my saved trials
Texas Children's Hospital
6621 Fannin St
Houston, Texas 77030
(832) 824-1000
Texas Children's Hospital Texas Children's Hospital, located in Houston, Texas, is a not-for-profit organization whose...
?
mi
from
Houston, TX
Click here to add this to my saved trials
Riley Hospital for Children
705 Riley Hospital Dr
Indianapolis, Indiana 46202
(317) 944-5000
Riley Hospital for Children Riley Hospital for Children at IU Health is a place of...
?
mi
from
Indianapolis, IN
Click here to add this to my saved trials
University of Iowa Children's Hospital
Iowa City, Iowa 52242
Phone: 319-384-5280
?
mi
from
Iowa City, IA
Click here to add this to my saved trials
University of Louisville/Kosair Children's Hospital
Louisville, Kentucky 40202
?
mi
from
Louisville, KY
Click here to add this to my saved trials
University of South Alabama
307 N University Blvd
Mobile, Alabama 36688
(251) 460-6101
Phone: 251-405-5172
University of South Alabama "University of South Alabama is a public institution that was founded...
?
mi
from
Mobile, AL
Click here to add this to my saved trials
Rutgers University
New Brunswick, New Jersey 08901
?
mi
from
New Brunswick, NJ
Click here to add this to my saved trials
Cohen Children's Medical Center
New Hyde Park, New York 11040
?
mi
from
New Hyde Park, NY
Click here to add this to my saved trials
Children's Hospital of New Orleans
New Orleans, Louisiana 70118
?
mi
from
New Orleans, LA
Click here to add this to my saved trials
UCSF Benioff Children's Hospital
Oakland, California 94609
?
mi
from
Oakland, CA
Click here to add this to my saved trials
Phoenix Children's Hospital
1919 E Thomas Rd
Phoenix, Arizona 85006
(602) 933-1000
Phoenix Children's Hospital Phoenix Children's Hospital has provided hope, healing, and the best healthcare for...
?
mi
from
Phoenix, AZ
Click here to add this to my saved trials
Children's Hospital of Pittsburgh
3414 Fifth Avenue
Pittsburgh, Pennsylvania 15213
Phone: 412-692-6467
?
mi
from
Pittsburgh, PA
Click here to add this to my saved trials
University of Pittsburgh Medical Center
200 Lothrop St
Pittsburgh, Pennsylvania 15213
University of Pittsburgh Medical Center UPMC is one of the leading nonprofit health systems in...
?
mi
from
Pittsburgh, PA
Click here to add this to my saved trials
Randall Children's Hospital
Portland, Oregon 97227
Phone: 503-276-9376
?
mi
from
Portland, OR
Click here to add this to my saved trials
Children's Hospital of Richmond
Richmond, Virginia 23298
Phone: 804-628-0212
?
mi
from
Richmond, VA
Click here to add this to my saved trials
Golisano Children's Hospital at URMC
Rochester, New York 14642
Phone: 585-273-3159
?
mi
from
Rochester, NY
Click here to add this to my saved trials
University of California at Davis Health System
Sacramento, California 95817
?
mi
from
Sacramento, CA
Click here to add this to my saved trials
Rady Children's Hosptial
San Diego, California 92123
?
mi
from
San Diego, CA
Click here to add this to my saved trials
All Children's Hospital
501 6th Avenue South
St. Petersburg, Florida 33701
(727) 898-7451
All Children's Hospital All Children's Hospital provides expert pediatric care for children and families from...
?
mi
from
St. Petersburg, FL
Click here to add this to my saved trials
Harbor-UCLA Medical Center
Torrence, California 90502
Phone: 310-222-4156
?
mi
from
Torrence, CA
Click here to add this to my saved trials
Howard University
Washington, District of Columbia 20060
?
mi
from
Washington,
Click here to add this to my saved trials
Al DuPont Hospital for Children
Wilmington, Delaware 19803
?
mi
from
Wilmington, DE
Click here to add this to my saved trials