Pharmacokinetics Study of AMG 423 in Healthy Subjects and Subjects With Various Degrees of Renal Insufficiency

Inclusion Criteria:

- Men or women ≥18 years of age

- Laboratory test values (clinical chemistry and hematology)within normal limits,
(other than test values out of the normal range for subjects with CKD [groups 1 and 3
through 5]), or clinically acceptable to the investigator and sponsor at screening
and day -3

- Free of any clinically significant disease or condition(s) (other than that
consistent with CKD for subjects in groups 1 and 3 through 5) that require a
physician's care and/or would interfere with the evaluations, procedures, or
participation in the study per the investigator's discretion;

Exclusion Criteria:

- Subjects whose second MDRD eGFR result during the screening period is not within 10%
of the first eGFR result

- Subjects who have received a functioning renal transplant within the past year

- Subjects with ESRD who do not have a functioning hemodialysis access

- Subjects with hemodynamic instability during hemodialysis

- Subjects whose renal insufficiency is due to active autoimmune renal disease

- Subjects with renal insufficiency or ESRD requiring hemodialysis and Troponin I >
upper limit of normal (ULN) at screening or day -3

- Subjects with history of heart disease or unstable angina within the last 3 months

- Subjects with uncontrolled diabetes (Hb1Ac > 8%) and/or subjects who are able but
unwilling to adhere to the required fasting intervals