Mechanisms of Pharyngeal Collapse in Sleep Apnea, Study B
| Status: | Completed |
|---|---|
| Conditions: | Insomnia Sleep Studies, Pulmonary |
| Therapuetic Areas: | Psychiatry / Psychology, Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 21 - 65 |
| Updated: | 4/2/2016 |
| Start Date: | December 2012 |
| End Date: | December 2014 |
| Contact: | Pedro R Genta, MD |
| Email: | pgenta@partners.org |
| Phone: | (617) 732-6541 |
In obstructive sleep apnea (OSA), the upper airway recurrently closes during sleep. The
mechanisms that lead to airway closure are not completely understood. Some studies have
shown that there is progressive narrowing of the pharyngeal airway across breaths during
expiration (Progressive Expiratory Narrowing, PEN) preceding an obstructive apnea. The cause
of PEN is unknown. The investigators will test if lung volumes and low respiratory drive
play a role in PEN.
mechanisms that lead to airway closure are not completely understood. Some studies have
shown that there is progressive narrowing of the pharyngeal airway across breaths during
expiration (Progressive Expiratory Narrowing, PEN) preceding an obstructive apnea. The cause
of PEN is unknown. The investigators will test if lung volumes and low respiratory drive
play a role in PEN.
The mechanisms that lead to airway closure in OSA are not completely understood. Some
studies have shown that there is progressive narrowing of the pharyngeal airway across
breaths during expiration (Progressive Expiratory Narrowing, PEN) preceding an obstructive
apnea.
The investigators will test if lung volumes and low respiratory drive play a role in PEN. To
this end, the investigators will visualize the pharynx of sleep apnea patients during sleep
using a thin endoscope during sleep while simultaneously measuring lung volumes,
genioglossus electromyogram, and pharyngeal pressure during flow-limited breaths. Flow
limitation will be induced by sustained reductions of continuous positive airway pressure
(CPAP).
studies have shown that there is progressive narrowing of the pharyngeal airway across
breaths during expiration (Progressive Expiratory Narrowing, PEN) preceding an obstructive
apnea.
The investigators will test if lung volumes and low respiratory drive play a role in PEN. To
this end, the investigators will visualize the pharynx of sleep apnea patients during sleep
using a thin endoscope during sleep while simultaneously measuring lung volumes,
genioglossus electromyogram, and pharyngeal pressure during flow-limited breaths. Flow
limitation will be induced by sustained reductions of continuous positive airway pressure
(CPAP).
Inclusion Criteria:
- Normal subjects or patients with OSA
Exclusion Criteria:
- Any unstable cardiac condition (other than well controlled hypertension) or pulmonary
problems.
- Any medication known to influence breathing, sleep/arousal or muscle physiology
- Concurrent sleep disorders (insomnia, narcolepsy, central sleep apnea or parasomnia)
- Claustrophobia
- Inability to sleep supine
- Allergy to lidocaine or oxymetazoline hydroclhoride
- For women: Pregnancy
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