Mechanisms of Pharyngeal Collapse in Sleep Apnea, Study C
| Status: | Completed |
|---|---|
| Conditions: | Insomnia Sleep Studies, Pulmonary |
| Therapuetic Areas: | Psychiatry / Psychology, Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 21 - 65 |
| Updated: | 4/2/2016 |
| Start Date: | December 2012 |
| End Date: | December 2014 |
| Contact: | Pedro R Genta, MD |
| Email: | pgenta@partners.org |
| Phone: | (617) 732-6541 |
In obstructive sleep apnea (OSA), the upper airway recurrently closes during sleep. The
mechanisms that lead to airway closure are not completely understood. Models to study
mechanisms of airway collapse have been proposed. However, these models have not been tested
in the human upper airway. Gas density and viscosity are different gas properties that
influence upper airway collapse and are variables of different models. In this study,
subjects will breathe gas mixtures of different densities and viscosities for brief periods
of time in order to test those models.
mechanisms that lead to airway closure are not completely understood. Models to study
mechanisms of airway collapse have been proposed. However, these models have not been tested
in the human upper airway. Gas density and viscosity are different gas properties that
influence upper airway collapse and are variables of different models. In this study,
subjects will breathe gas mixtures of different densities and viscosities for brief periods
of time in order to test those models.
Models to study mechanisms of airway collapse have been proposed. However, these models have
not been tested in the human upper airway. Gas density and viscosity are different gas
properties that influence upper airway collapse and are variables of different models.
In this study, subjects will breathe gas mixtures of different densities (helium and
sulfur-hexafluoride) or viscosity (neon) for brief periods of time during flow-limited
breaths. Flow limitation will be induced by sustained reductions of continuous positive
airway pressure (CPAP). The investigators will test some models of upper airway collapse by
observing if flow while breathing different gas mixtures scales according to the differences
in density and viscosity.
not been tested in the human upper airway. Gas density and viscosity are different gas
properties that influence upper airway collapse and are variables of different models.
In this study, subjects will breathe gas mixtures of different densities (helium and
sulfur-hexafluoride) or viscosity (neon) for brief periods of time during flow-limited
breaths. Flow limitation will be induced by sustained reductions of continuous positive
airway pressure (CPAP). The investigators will test some models of upper airway collapse by
observing if flow while breathing different gas mixtures scales according to the differences
in density and viscosity.
Inclusion Criteria:
- Normal subjects or patients with OSA
Exclusion Criteria:
- Any unstable cardiac condition (other than well controlled hypertension) or pulmonary
problems.
- Any medication known to influence breathing, sleep/arousal or muscle physiology
- Concurrent sleep disorders (insomnia, narcolepsy, central sleep apnea or parasomnia)
- Claustrophobia
- Inability to sleep supine
- Allergy to lidocaine or oxymetazoline hydrochloride
- For women: Pregnancy
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