Effects of Aging and Aerobic Exercise Training on Brain Glucose Metabolism
| Status: | Active, not recruiting |
|---|---|
| Conditions: | Neurology |
| Therapuetic Areas: | Neurology |
| Healthy: | No |
| Age Range: | 18 - 80 |
| Updated: | 8/16/2018 |
| Start Date: | October 2012 |
| End Date: | December 2019 |
Effect of Aging and Aerobic Exercise Training on Brain Glucose Metabolism
Aging is associated with a loss of brain function and conditions such as dementia and
Alzheimer's disease. It is likely that decreased brain metabolism is contributing to the
progression of age related degenerative diseases. Aerobic exercise training can increase
brain volumes and is associated with decreased risk for degenerative brain conditions.
However, little is know about the changes that occur to brain metabolism with aerobic
training and aging.
Alzheimer's disease. It is likely that decreased brain metabolism is contributing to the
progression of age related degenerative diseases. Aerobic exercise training can increase
brain volumes and is associated with decreased risk for degenerative brain conditions.
However, little is know about the changes that occur to brain metabolism with aerobic
training and aging.
Healthy sedentary adults aged 18-30 or 65-80 years of all ethnicities will be eligible.
Pregnant women, children, prisoners or other at risk populations will not be recruited.
Inclusion Criteria:
- Age 18-30 years or 65-80 years
Exclusion Criteria:
- Body mass index (BMI) >31 kg/m2
- Smoking
- Pregnancy
- Participation in structured exercise (>2 times per week for 30 minutes or longer)
- Cardiovascular, metabolic (type 2 diabetes, fasting plasma glucose at or above 110
mg/dL and untreated hypo- or hyperthyroidism) or renal disease
- Orthopedic problems that would keep them from being able to ride an exercise bicycle,
lift weights or do a combination of these exercise
- Medications that are known to impact on mitochondrial function: Corticosteroids,
opiates, benzodiazepines, tricyclic antidepressants, beta blockers, sulfonylureas,
insulin, anticoagulants, barbiturates, insulin sensitizers, fibrates (PPAR gamma
agonist)
- Claustrophobia
We found this trial at
1
site
Mayo Clinic Rochester Mayo Clinic is a nonprofit worldwide leader in medical care, research and...
Click here to add this to my saved trials
