GLOBAL Clinical Study

Inclusion Criteria:

1. Ages 18-90

2. Caucasian and of Non-Hispanic or Non-Latino origin

3. Referral for coronary CT angiography to evaluate for presence of CAD

4. The patient has signed the appropriate Institutional Review Board approved Informed
Consent Form

Exclusion Criteria:

1. Immunosuppressive or immunomodulatory therapy including any dose of systemic
corticosteroids in the preceding 30 days (except if steroids are administered as
pre-medication prior to contrast administration for CT scan within 24 hours).

2. Chemotherapy in the preceding year

3. Major surgery in the preceding 2 months

4. Blood or blood product transfusion in the preceding 2 months

5. Subjects for whom coronary CT angiography is contraindicated per institutional
standard of care

6. Subjects with previous coronary arterial revascularization (PCI or CABG)

7. Subjects with atrial fibrillation/flutter or frequent irregular or rapid heart
rhythms, which occurred within the past 3 months

8. Subjects with a pacemaker or implantable cardioverter-defibrillator implant

9. Active congestive heart failure or the presence of known non-ischemic cardiomyopathy

10. Known genetic disorders of atherosclerosis, lipid or lipoprotein metabolism