Kudzu Effects on Brain Ethanol Levels: Proton Spectroscopy Assessment

Inclusion Criteria:

- Capable of understanding and complying with the protocol

- Good physical and mental health (normal physical exam, ECG, blood and urine
chemistries, no psychopathologies)

- Body Mass Index between 18-30, inclusive

- Age 21-40 years

- Moderate alcohol drinkers (less than 20 drinks/week)

- Have a stable living situation with current postal address

- No contraindications to MR scanning (see MR scanning exclusion criteria below)

Exclusion Criteria:

- Concurrent diagnosis of Axis I disorder

- Current or past alcohol dependence; may meet criteria for alcohol abuse. Other drug
dependence acceptable only if greater than 3 years.

- Current drug abuse (other than alcohol or marijuana abuse). Past drug abuse is
acceptable.

- Subjects cannot be actively seeking treatment for any drug or alcohol dependence.

- Subjects cannot use marijuana more than once a week. Marijuana abuse/dependence are
acceptable if the use criteria is met.

- Maintained on an antipsychotic or antidepressant medication; taking prescription
medications except certain short-term anti fungal agents and some tropical creams for
dermal conditions.

- Tobacco use greater than 10 cigarettes per day

- History of major head trauma resulting in cognitive impairment or history of seizure
disorder

- Heavy caffeine use (greater than 500 mg on a regular, daily basis)

- For female volunteers, a positive pregnancy test