ADenosine Vasodilator Independent Stenosis Evaluation II - ADVISE II

Inclusion Criteria:

- - Patient must be > 18 and < 85 years of age

- Willing to participate and able to understand, read and sign the informed consent
document before the planned procedure

- Eligible for coronary angiography and/or percutaneous coronary intervention

- Coronary artery disease with at least 1 or more visually assessed coronary stenoses
(>40% diameter stenosis) in native major epicardial vessel or its branches by
coronary angiogram.

- Stable angina or acute coronary syndromes (non-culprit vessels only and outside of
primary intervention during acute myocardial infarction)

Exclusion Criteria:

- - Known contraindication to adenosine administration

- Implanted temporary or permanent artificial pacemakers, Left Bundle Branch Block
(LBBB), 1st and 2nd degree AV Block

- STEMI or non STEMI within 48 hours of procedure

- Any contraindications for FFR interrogation or percutaneous coronary intervention
(PCI) as determined by the investigator

- Severe vessel tortuosity and/or severe calcification by angiogram

- Significant valvular pathology (moderate or severe AS/AR/MS/MR)

- Previous Coronary Artery Bypass surgery with patent grafts to the interrogated vessel

- Weight >200kg (441 lbs.)

- Hemodynamic instability at the time of intervention (heart rate<50 beats per minute,
systolic blood pressure <90mmHg) balloon pump

- Significant hepatic disease, renal disease, lung disease (pulmonary chronic pulmonary
obstructive disease) and/or malignant disease with unfavorable prognosis or
presenting with abnormal serum laboratory values that the physician believes is
clinically significant

- Contraindication to antithrombotic regimen or anticoagulation therapy

- History of or known reaction or sensitivity to contrast agent and is unable to be
pre-medicated

- Left main stenosis, tandem stenosis separated by more than 5 mm that require
separate pressure guide wire interrogation or PCI (not to be interrogated or treated
as a single stenosis), or total occlusions

- Known Left ventricular ejection fraction (LVEF) <30%