Normative Data of Brain Network Activation

Currently, there is no reliable, bedside, and non-invasive method for assessing connectivity
changes in electrophysiological activity of the brain associated with brain-related
pathologies, e.g., concussion, ADHD, autistic spectrum disorders (ASD), etc. Event Related
Potentials (ERPs), which are temporal reflections of the neural mass electrical activity of
cells in specific regions of the brain that occur in response to stimuli, may offer such a
method, as they provide both a non-invasive and portable measure of brain function. The ERPs
provide excellent temporal information, but spatial resolution for ERPs has traditionally
been limited. However, by using high-density electroencephalograph (EEG) recording spatial
resolution for ERPs is improved significantly. The paradigm for the current study will
combine neurophysiological knowledge with mathematical signal processing and pattern
recognition methods (BNA) to temporally and spatially map brain function, connectivity and
synchronization.

The need of objective measures that will help the clinician in its decision making in
brain-related pathologies is recognized. BNA is a new imaging modality that has been
developed to fill this gap.

Inclusion Criteria:

- Age 15-30 years.

- Able to speak, read and understand English sufficiently to understand the nature of
the study, and to allow completion of all study assessments.

- Willingness to participate and able to give informed assent (child) and/or consent
(parent for minors or adult 18+ years of age for self).

Exclusion Criteria:

- Currently participate in a contact sport (e.g., football, hockey, soccer, rugby,
lacrosse, martial arts).

- Currently with lice or open wounds on scalp.

- Any chronic disease as determined by clinical evaluation and medical history.

- Any psychiatric disorder, e.g., depression, bipolar disorder, schizophrenic disorder,
etc. as determined by clinical evaluation and the Mini International Neuropsychiatric
Interview (MINI)

- Any CNS neurologic disorder, e.g., epilepsy, seizures, etc. as determined by clinical
evaluation

- History of Special education, e.g., reading disorder (dyslexia), writing disorder
(dysgraphia), math disorder (dyscalculia), nonverbal learning disorder.

- History of any medication affecting CNS within the last 3 months, e.g.,
antidepressants, anticonvulsants, psychostimulants, first generation antihistamines,
etc.

- Substance abuse in the last 3 months.

- Significant sensory deficits, e.g., deafness or blindness.

- History of any clinically significant brain trauma as determined by the investigator