Genetic and Neural Predictors of Adolescent Depression
| Status: | Recruiting |
|---|---|
| Conditions: | Depression, Major Depression Disorder (MDD) |
| Therapuetic Areas: | Psychiatry / Psychology, Pulmonary / Respiratory Diseases |
| Healthy: | No |
| Age Range: | 12 - Any |
| Updated: | 4/17/2018 |
| Start Date: | April 2013 |
| End Date: | December 2020 |
| Contact: | Colin Stanton |
| Email: | cstanton@mclean.harvard.edu |
| Phone: | 617-855-4240 |
Towards Identification of Genetic and Neural Predictors of Adolescent Depression
This study aims to examine the relationship between mood and brain activity in adolescent
girls in order to better understand the genetic and neural predictors of adolescent
depression. The participants in this study will be healthy female adolescents aged 12-14 and
their mothers. They will participate for a total of six months. Adolescent participants will
have three study sessions at McLean Hospital, and during two of them, their mothers will also
have assessments. Adolescent assessments will include interviews, questionnaires, computer
tasks, and collection of a saliva sample for genetic analyses. Their second study visit will
include an fMRI scan. Parent assessments will include an interview, questionnaires, and a
computer task.
girls in order to better understand the genetic and neural predictors of adolescent
depression. The participants in this study will be healthy female adolescents aged 12-14 and
their mothers. They will participate for a total of six months. Adolescent participants will
have three study sessions at McLean Hospital, and during two of them, their mothers will also
have assessments. Adolescent assessments will include interviews, questionnaires, computer
tasks, and collection of a saliva sample for genetic analyses. Their second study visit will
include an fMRI scan. Parent assessments will include an interview, questionnaires, and a
computer task.
Adult Cohort
A. MDD Mothers Cohort Inclusion Criteria:
- Current or past Major Depressive Disorder
- English as first language or English fluency
- Biological daughter who meets inclusion/exclusion criteria for High Risk Female
Adolescent
B. Healthy Control Mothers Cohort Inclusion Criteria:
- No history of psychopathology
- English as first language or English fluency
- Biological daughter who meets inclusion/exclusion criteria for Healthy Female
Adolescent
Adolescent Cohort
General Inclusion Criteria for Adolescent Cohorts:
- Female
- Ages 12-14
- English as first language or English fluency
- Right handed
General Exclusion Criteria for Adolescent Cohorts:
- Past or present diagnosis of Major Depressive Disorder
- Past or present diagnosis of any anxiety disorder
- Past or present diagnosis of Bipolar Disorder
- Past or present diagnosis of ADHD
- Presence of medical or neurological illness (head injury, loss of consciousness
greater than 5 minutes, seizure)
- Current use of psychotropic medication
- Presence of any contraindication for MRI:
- Cardiac pacemakers
- Metal clips on blood vessels (also called stents)
- Artificial heart valve, artificial arms, hands, legs, etc.
- Brain stimulator devices
- Implanted drug pumps
- Ear or eye implants
- Known metal fragments in eyes
- Exposure to metal filings or shrapnel (sheet metal workers, welders, and others)
- Other metallic surgical hardware in vital area
- Certain tattoos with metallic ink
- Certain IUDs containing metal
- Certain transdermal (skin) patches such as:
- NicoDerm (nicotine for tobacco dependence)
- Transderm Scop (scopolamine for motion sickness)
- Ortho Evra (birth control)
- Positive urine pregnancy test
C. High Risk Female Adolescent Additional Inclusion Criterion:
• Biological daughter of participant in the MDD Mothers cohort
D. Healthy Female Adolescent Additional Inclusion Criterion:
• Biological daughter of participant in the Healthy Control Mothers cohort
We found this trial at
1
site
115 Mill St
Belmont, Massachusetts 02478
Belmont, Massachusetts 02478
(617) 855-2000
Principal Investigator: Randy P. Auerbach, PhD
Phone: 617-855-4240
McLean Hospital McLean Hospital is a comprehensive psychiatric hospital committed to providing easy access to...
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