Effect of Vitamin D Supplementation on Endothelial Function in Obese Adolescents
| Status: | Completed |
|---|---|
| Conditions: | Obesity Weight Loss, Other Indications, Cardiology, Gastrointestinal |
| Therapuetic Areas: | Cardiology / Vascular Diseases, Endocrinology, Gastroenterology, Other |
| Healthy: | No |
| Age Range: | 12 - 18 |
| Updated: | 5/5/2014 |
| Start Date: | November 2012 |
| End Date: | December 2014 |
| Contact: | Asma Javed, MBBS |
| Email: | javed.asma@mayo.edu |
| Phone: | 507-284-3300 |
Vitamin D deficiency has been linked to endothelial dysfunction in adults. Obese adolescents
have a high prevalence of Vitamin D deficiency as well as evidence of endothelial
dysfunction. Our hypothesis is that supplementation of Vitamin D deficient adolescents with
Vitamin D would lead to improvement in endothelial dysfunction.
have a high prevalence of Vitamin D deficiency as well as evidence of endothelial
dysfunction. Our hypothesis is that supplementation of Vitamin D deficient adolescents with
Vitamin D would lead to improvement in endothelial dysfunction.
Inclusion Criteria:
1. Age 12-18 years
2. BMI >95% for age and gender
3. 25 (OH) D levels less than 30 ng/ml
Exclusion Criteria:
1. 25 (OH) D levels >30 ng/mL
2. Serum calcium >10.4 mg/dL
3. Serum phosphorus > 4.7 mg/dl
4. Pregnancy or nursing
5. Current cancer
6. Patients on vitamin D3 supplementation exceeding 400 IU/day
7. Hypertension defined as Blood Pressure over the 95th percentile for age, gender and
height
8. Dietary calcium intake exceeding 1500 mg/day,
9. Hepatic or renal disorders
10. Type 1 or type 2 diabetes mellitus
11. Subjects receiving insulin, metformin, or oral hypoglycemic medications
12. Subjects with malabsorption disorders (celiac disease, cystic fibrosis,inflammatory
bowel disease)
We found this trial at
1
site
Mayo Clinic Rochester Mayo Clinic is a nonprofit worldwide leader in medical care, research and...
Click here to add this to my saved trials
