Safety and Efficacy Study of Gevokizumab to Treat Non-infectious Uveitis Controlled With Systemic Treatment



Status:Terminated
Conditions:Cervical Cancer, Ocular
Therapuetic Areas:Oncology, Ophthalmology
Healthy:No
Age Range:18 - Any
Updated:7/13/2016
Start Date:October 2012

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A Randomized, Double-masked, Placebo-controlled Study of the Safety and Efficacy of Gevokizumab in the Treatment of Subjects With Non-infectious Intermediate, Posterior, or Pan-uveitis Currently Controlled With Systemic Treatment

The purpose of this study is to evaluate the efficacy of gevokizumab in reducing the risk of
recurrent uveitic disease in subjects with non-infectious uveitis whose disease is currently
controlled with systemic treatment.


Inclusion Criteria:

- Diagnosis of non-infectious intermediate, posterior, or pan- uveitis in at least one
eye

- Controlled uveitic disease in both eyes

- Stable dose of oral corticosteroids in combination with selected stable
immunosuppressive therapy

- Effective contraceptive measures

Exclusion Criteria:

- Infectious uveitis and masquerade syndromes

- Isolated anterior uveitis

- Contraindication to mydriatics

- Active tuberculosis disease

- History of allergic or anaphylactic reactions to monoclonal antibodies

- History of recurrent infection or predisposition to infection; active ocular
infection

- Pregnant or nursing women

Other protocol-defined inclusion/exclusion criteria may apply
We found this trial at
52
sites
San Luis Obispo, California 93405
2069
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from 43215
San Luis Obispo, CA
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2054
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Ashland, OR
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436
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Atlanta, GA
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1069
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Austin, TX
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344
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Baltimore, MD
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130
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Beachwood, OH
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343
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Belmont, NC
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Beverly Hills, California 90211
1979
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Beverly Hills, CA
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468
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Bloomfield, NJ
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522
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Bridgeport, CT
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641
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Cambridge, MA
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1655
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Chandler, AZ
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Charlotte, North Carolina 28207
350
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Charlotte, NC
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274
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Chicago, IL
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127
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Cleveland, OH
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910
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Dallas, TX
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163
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Detroit, MI
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809
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Ellsworth, ME
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857
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Fargo, ND
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1174
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Golden, CO
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991
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Houston, TX
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166
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Indianapolis, IN
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460
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Iowa City, IA
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173
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Jackson, MI
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283
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Knoxville, TN
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823
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Lakeland, FL
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1164
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Littleton, CO
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1972
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Los Angeles, CA
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508
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Memphis, TN
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116
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Middleburg Heights, OH
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1294
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Mission, TX
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422
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Norfolk, VA
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5377
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Olivos,
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682
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Omaha, NE
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Palisades Park, New Jersey 07650
478
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Palisades Park, NJ
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416
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Philadelphia, PA
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1662
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Phoenix, AZ
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1915
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Redlands, CA
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559
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Rochester, MN
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176
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Royal Oak, MI
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2039
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Sacramento, CA
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1513
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Salt Lake City, UT
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1144
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San Antonio, TX
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1960
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Santa Ana, CA
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395
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St. Louis, MO
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842
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St. Petersburg, FL
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831
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Tampa, FL
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477
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Teaneck, NJ
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1911
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Victorville, CA
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634
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Waltham, MA
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328
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Washington,
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306
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Winston-Salem, NC
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