Management of Recurrent Croup
| Status: | Terminated |
|---|---|
| Conditions: | Infectious Disease |
| Therapuetic Areas: | Immunology / Infectious Diseases |
| Healthy: | No |
| Age Range: | Any - 15 |
| Updated: | 11/15/2017 |
| Start Date: | September 2012 |
| End Date: | June 2014 |
Management of Recurrent Croup: Comparison Between Inhaled Fluticasone and Oral Prednisolone
Presently children who experience recurring croup symptoms receive a variety of treatments.
This is because it is not clear which treatments may be best. Some children are given inhaled
steroids (similar to what children with asthma use). Others are carefully watched and
cautioned to avoid potential triggers (certain foods, environmental allergens, etc), and
should episodes of croup recur they are treated with a short course of oral steroids. The
purpose of this study is to compare two safe and clinically appropriate methods for treating
recurrent croup, daily inhaled steroids versus observation with oral steroids on an as needed
basis, to see if either is useful in preventing future episodes of croup.
This is because it is not clear which treatments may be best. Some children are given inhaled
steroids (similar to what children with asthma use). Others are carefully watched and
cautioned to avoid potential triggers (certain foods, environmental allergens, etc), and
should episodes of croup recur they are treated with a short course of oral steroids. The
purpose of this study is to compare two safe and clinically appropriate methods for treating
recurrent croup, daily inhaled steroids versus observation with oral steroids on an as needed
basis, to see if either is useful in preventing future episodes of croup.
Inclusion Criteria:
- Pediatric population: 6 months to 15 years of age
- 2 or more episodes of croup in 12 month period
- croup defined as acute onset inspiratory stridor, barking cough, with respiratory
distress.
Exclusion Criteria:
- Grade 3 or 4 subglottic stenosis
- Subglottic hemangioma
- Posterior laryngeal cleft
- Recurrent respiratory papillomatosis
- External compression (Innominate artery compression, mediastinal mass, (double aortic
arch, etc)
- Symptoms or signs suggesting another cause of stridor, such as epiglottitis, bacterial
tracheitis, or supraglottic foreign body
- Tracheomalacia/ bronchomalacia severe enough to cause respiratory distress
- Current steroid therapy for previously diagnosed condition, i.e. reactive airway
disease.
- Other medical conditions necessitating chronic steroid utilization
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