Validation of Pulse Wave Doppler Demodulation Algorithm for the Continuous, Non-invasive Measurement of Blood Flow Velocity
| Status: | Recruiting |
|---|---|
| Healthy: | No |
| Age Range: | 18 - 65 |
| Updated: | 5/3/2014 |
| Start Date: | December 2012 |
| Contact: | Robert H Thiele, MD |
| Email: | rht7w@virginia.edu |
| Phone: | 434-924-2283 |
The investigators hypothesize that performance of fast-Fourier transformation on the raw
Doppler signals obtained from ascending aortic blood flow will recreate the pulse wave
Doppler trace visualized on modern echocardiography machines, and that this will allow for
the measurement and recording of vascular flow waveforms
Doppler signals obtained from ascending aortic blood flow will recreate the pulse wave
Doppler trace visualized on modern echocardiography machines, and that this will allow for
the measurement and recording of vascular flow waveforms
Currently there is no commercially available mechanism for the measurement of blood flow
velocity waveforms non-invasively. Blood flow velocity waveforms require the use of
invasive catheters, thus precluding clinical use. Such information would allow the
researcher / practitioner the ability to continuously measure blood flow, pulse pressure,
and the pulsatility index of any vascular structure accessible by ultrasound with minimal
additional risk to the subject / patient. This data, when combined with arterial blood
pressure data, could also be used to measure peripheral pressure volume loops as well as
aortic vascular impedance, both of which cannot be currently measured in vivo.
The ability to measure blood flow velocity waveforms at high temporal resolution would
provide clinicians with new tools for hemodynamic optimization (both a novel means of
estimating myocardial oxygen consumption [pressure volume area] as well as afterload [aortic
vascular impedance]) and researchers with the ability to conduct hemodynamic experiments
that were not previously possible. This work will serve as the foundation for several other
related projects which depend on the ability to continuously record blood flow velocity
waveforms.
velocity waveforms non-invasively. Blood flow velocity waveforms require the use of
invasive catheters, thus precluding clinical use. Such information would allow the
researcher / practitioner the ability to continuously measure blood flow, pulse pressure,
and the pulsatility index of any vascular structure accessible by ultrasound with minimal
additional risk to the subject / patient. This data, when combined with arterial blood
pressure data, could also be used to measure peripheral pressure volume loops as well as
aortic vascular impedance, both of which cannot be currently measured in vivo.
The ability to measure blood flow velocity waveforms at high temporal resolution would
provide clinicians with new tools for hemodynamic optimization (both a novel means of
estimating myocardial oxygen consumption [pressure volume area] as well as afterload [aortic
vascular impedance]) and researchers with the ability to conduct hemodynamic experiments
that were not previously possible. This work will serve as the foundation for several other
related projects which depend on the ability to continuously record blood flow velocity
waveforms.
Inclusion Criteria:
- 18-65
- Healthy
Exclusion Criteria:
- Cannot visualize ascending aorta with ultrasound
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