HLA-B35 Alleles and AIDS
| Status: | Archived |
|---|---|
| Conditions: | HIV / AIDS |
| Therapuetic Areas: | Immunology / Infectious Diseases |
| Healthy: | No |
| Age Range: | Any |
| Updated: | 7/1/2011 |
Comparison of HIV-1 Epitopes That May be Recognized by HLA-B*3501 (PY) and -B*3503 (Px) Early After Seroconversion and After Development of AIDS
This study will identify variations in the genome of the human immunodeficiency virus (HIV)
early after infection and following the development of AIDS. It will analyze genetic
material and clinical data from HIV-positive individuals to assess differences in viral
epitopes between patients with two different gene alleles (alternative forms of a
gene)-B*3501 and B*3503. (An epitope is a molecular region on the surface of an antigen
capable of eliciting an immune response and of combining with the specific antibody produced
by such a response.)
HIV disease in people with the B*3503 allele progresses significantly faster than it does in
people with the B*3501 allele. This study might provide information that is potentially
useful in developing a successful HIV vaccine.
Blood samples and clinical data for analysis will be obtained from the Johns Hopkins
Bloomberg School of Public Health; the University of Pittsburgh; the John H. Stroger, Jr.
Hospital of Cook County; the Howard Brown Health Center; Northwestern University; and the
University of California at Los Angeles.
The purpose of this study is to identify variations in the genome of HIV early after
infection and following the development of AIDS to determine the location of escape
mutations that might provide information about potential B*35 epitopes. These data will be
useful in explaining the difference in disease progression between individuals possessing
B*35 Px alleles and those with B*35 PY alleles. We have previously shown that individuals
with B*35 Px alleles progress at a significantly faster rate compared to those with B*35 PY
alleles. This study might provide information which is potentially useful in the
development of a successful HIV vaccine.
We found this trial at
7
sites
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Northwestern University Northwestern is recognized both nationally and internationally for the quality of its educational...
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1240 North Mission Road # L919
Los Angeles, California 90033
Los Angeles, California 90033
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University of Pittsburgh The University of Pittsburgh is a state-related research university, founded as the...
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9000 Rockville Pike
Bethesda, Maryland 20892
Bethesda, Maryland 20892
301-496-2563
National Institutes of Health Clinical Center The National Institutes of Health (NIH) Clinical Center in...
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