Liraglutide In Overweight Patients With Type 1 Diabetes

Inclusion Criteria:

1) Type 1 Diabetes on continuous subcutaneous insulin infusion (CSII; also known as insulin
pump) or multiple (four or more) injections of insulin per day. 2) Using a continuous
glucose monitoring device (CGM) or regularly measuring their blood sugars four times daily.
3) HbA1c of less than 8.5%. 4) Well versed with carbohydrate counting. 5) Age 18-75 years
6) BMI≥ 25kg/m2 7) Age at diagnosis of type 1 diabetes should be <30 years. 8) evidence of
auto-immunity to beta cells (GAD-65 and islet cell antibody screen)

Exclusion Criteria:

1)Type 1 diabetes for less than 6 months; 2)Coronary event or procedure (myocardial
infarction, unstable angina, coronary artery bypass, surgery or coronary angioplasty) in
the previous four weeks; 3)Hepatic disease (transaminase > 3 times normal) or cirrhosis;
4)Renal impairment (serum eGFR <30ml/min/1.73m2); 5)HIV or Hepatitis B or C positive
status; 6)Participation in any other concurrent clinical trial; 7)Any other
life-threatening, non-cardiac disease; 8)Use of an investigational agent or therapeutic
regimen within 30 days of study. 9) history of pancreatitis 10) pregnancy 11) inability to
give informed consent 12) history of gastroparesis 13)history of medullary thyroid
carcinoma or MEN 2 syndrome. 14) Smokers will be advised not to change their amount of
smoking for the duration of the study; 15) Use of any agent other than insulin for
treatment of diabetes (metformin, pramlintide or thiazolidinediones.