Study of Two Surgical Drilling Techniques to Treat Juvenile Osteochondritis Dissecans of the Knee



Status:Recruiting
Healthy:No
Age Range:8 - 18
Updated:2/24/2018
Start Date:November 2012
End Date:April 2020
Contact:Elizabeth S Liotta, M.B.B.S.
Email:elizabeth.liotta@childrens.harvard.edu
Phone:857-218-3272

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Trial Summary
Trial Overview
Inclusion Criteria

Retro Versus Trans Articular Drilling for Juvenile Osteochondritis Dissecans of the Knee: A Multicenter, Randomized Controlled Trial

The purpose of this study is to compare the functional, clinical and radiographic outcomes
associated with trans-articular drilling versus retro-articular drilling, two commonly
employed techniques of operative treatment for stable forms of juvenile osteochondritis
dissecans (JOCD) lesions. This study also aims to better define the natural history of this
condition in its most commonly identified pathological state (as a stable lesion) following
surgical intervention by determining the rate of radiographic healing and any need for
secondary surgery.


Inclusion Criteria:

- Diagnosis of JOCD,

- Lesion located on the lateral aspect of the medial femoral condyle,

- Lesion considered stable based on MRI,

- Patient deemed skeletally immature based on MRI,

- Completed a course of conservative therapy.

Exclusion Criteria:

- Significant concomitant knee pathology (AVN, fracture, inflammatory arthritis, ACL
tear, discoid/meniscal tear, etc.)

- Lesion healed sufficiently and surgery is not recommended,

- Prior surgery on the affected knee,

- Diagnosis of metabolic bone disorder (e.g. osteogenesis imperfecta),

- Diagnosis of sickle cell disease,

- History of prolonged corticosteroid or chemotherapy treatment,
We found this trial at
14
sites
Connecticut Children's Medical Center
Farmington, Connecticut 06032
Principal Investigator: Carl W. Nissen, MD
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Cincinnati Children's Hospital Medical Center
3333 Burnet Avenue # Mlc3008
Cincinnati, Ohio 45229
 1-513-636-4200 
Principal Investigator: Eric J. Wall, MD
Cincinnati Children's Hospital Medical Center Patients and families from across the region and around the...
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St. Luke's Children's Hospital
Boise, Idaho 83702
Principal Investigator: Kevin G Shea, MD
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Boise, ID
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Children's Hospital Boston
Boston, Massachusetts 02115
Principal Investigator: Benton Heyworth, MD
Phone: 857-218-3272
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Boston, MA
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Rocky Mountain Hospital for Children
Centennial, Colorado 80112
Principal Investigator: John D. Polousky, MD
Phone: 720-979-0840
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Centennial, CO
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Kaiser Permanente Los Angeles
Los Angeles, California 90027
Principal Investigator: Jennifer M. Weiss, MD
Phone: 310-597-9216
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Los Angeles, CA
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Medical College of Wisconsin
8701 W Watertown Plank Rd
Milwaukee, Wisconsin
(414) 955-8296
Principal Investigator: Roger M. Lyon, MD
Medical College of Wisconsin The Medical College (MCW) of Wisconsin is a major national research...
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Milwaukee, WI
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Tennessee Orthopaedic Alliance
Nashville, Tennessee 37205
Principal Investigator: Christian N. Anderson, MD
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Nashville, TN
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Hospital for Special Surgery
535 E 70th St
New York, New York 10021
(212) 606-1000
Principal Investigator: Daniel Green, M.D.
Hospital for Special Surgery Founded in 1863, Hospital for Special Surgery is the nation
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New York, NY
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The Children's Hopstial of Philadelphia
Philadelphia, Pennsylvania 19104
Principal Investigator: Theodore J. Ganley, MD
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Philadelphia, PA
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Univ of Pennsylvania
3451 Walnut St
Philadelphia, Pennsylvania 19104
1 (215) 898-5000
Principal Investigator: James L. Carey, MD
Univ of Pennsylvania Penn has a long and proud tradition of intellectual rigor and pursuit...
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Philadelphia, PA
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Washington University School of Medicine
660 S Euclid Ave
Saint Louis, Missouri 63110
(314) 362-5000
Principal Investigator: Rick W. Wright, MD
Washington University School of Medicine Washington University Physicians is the clinical practice of the School...
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Saint Louis, MO
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Rady Children's Hospital
San Diego, California 92123
Principal Investigator: Henry G. Chambers, MD
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San Diego, CA
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Hospital for Sick Children
555 University Avenue
Toronto, Ontario M5G 1X8
Principal Investigator: M. Lucas Murnaghan, MD
Phone: (416) 823-4902
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