Light-Scattering Spectroscopy for Detection of Breast Cancer

PRIMARY OBJECTIVES: I. To evaluate whether light-scattering spectroscopy can reliably
distinguish between two subject groups: those with clinical stage II or stage III breast
cancer and those without breast cancer.

OUTLINE: Patients undergo light-scattering spectroscopy of the breast in addition to standard
of care as it relates to screening for breast cancer or treatment of breast cancer.

Inclusion Criteria:

- Participants who are breast cancer free (mammogram "negative" within 1 month of
testing) with the absence of clinical suspicion of breast cancer on physical exam or
with clinical stage II or stage III breast cancer. PLEASE NOTE: Recruitment for this
study is only limited to patients who are scheduled for a mammogram at USC. There is
no compensation to participants.

- Provision of informed consent prior to any study-related procedures

Exclusion Criteria:

- Females with tattoos on either or both breasts

- Females with nipple piercings on either or both breasts

- Females with skin piercings (aka microdermal anchor surface or microdermal piercings)
in either or both breasts

- Females unable to provide informed consent

- Females s/p treatment for breast cancer