Genetic Risk Factors for Lung Cancer in Non-Smoking Women in Xuan Wei and Fu Yuan Counties in Yun Nan Province, China

OBJECTIVES:

- Determine the health effects of smoky coal in non-smoking women from Xuan Wei and Fu
Yuan counties in China's Yun Nan province.

- Determine how different levels of exposure to smoky coal and other types of fuel affect
the amount of smoky coal emissions that are absorbed into the body.

- Determine genetic risk factors for lung cancer in the study population and how they
interact with smoky coal and PAH exposure.

OUTLINE: Patients wear small badges designed to measure the amount of particulate matter and
other chemicals they are exposed to and a small patch sampler on the wrist, neck, and
shoulder to measure the amount of smoky coal exposure to the skin.

Patients undergo collection of blood and urine samples over 2 days, buccal cells on 1 day,
and sputum samples over 5 days. Samples are analyzed by assays to test the ability to repair
PAH-damaged DNA and apoptotic capacity and to measure integrative markers of genomic
stability such as telomere length and oxidative damage in mitochondrial DNA.